Wang Yashuo, Wang Wei, Wang Bin, Wang Yunyang
College of Life Sciences, Qingdao University, China.
Institute of Oceanology, Chinese Academy of Sciences, China.
Gastroenterol Res Pract. 2020 Aug 3;2020:9824615. doi: 10.1155/2020/9824615. eCollection 2020.
Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (≤325 mg/day).
A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up till April 2020. Electronic databases include PUBMED, EMBASE, Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database. Two independent authors searched databases and reviewed abstracts for comprehensive studies keeping adequate study quality. Data of weighted odds ratios were statistically evaluated and potential bias was checked.
Among 446 publications, eight case-control researches, including 1601 patients, were deemed for this meta-analysis. Patients with diabetes were associated with a higher risk of GI hemorrhage than patients without diabetes: the summary ORs were 3.10 (95% CI, 2.35-4.09). The heterogeneity of the reports was not significant (Chi = 3.39, = 0.85; = 0%).
The meta-analysis showed that aspirin users with diabetes were more likely to have GI hemorrhage. Hence, when treating diabetics with aspirin, the increased risk of GI bleeding should be taken in consideration.
我们的目的是评估服用低剂量阿司匹林（≤325毫克/天）的患者中与糖尿病相关的胃肠道（GI）出血风险。
截至2020年4月，使用“GI出血”、“阿司匹林”和“糖尿病”的等效术语对英文和中文出版物进行系统检索。电子数据库包括PUBMED、EMBASE、Cochrane图书馆数据库、中国国家知识基础设施（CNKI）、万方数据库和维普数据库。两名独立作者检索数据库并审查摘要，以获取保持适当研究质量的综合研究。对加权比值比数据进行统计评估并检查潜在偏倚。
在446篇出版物中，八项病例对照研究（包括1601名患者）被纳入该荟萃分析。糖尿病患者发生GI出血的风险高于非糖尿病患者：汇总OR为3.10（95%CI，2.35-4.09）。报告的异质性不显著（Chi = 3.39， = 0.85； = 0%）。
荟萃分析表明，服用阿司匹林的糖尿病患者更易发生GI出血。因此，在用阿司匹林治疗糖尿病患者时，应考虑GI出血风险增加的情况。
