Khalaf Aysar, Hirmas Nader, Anwer Farah, Al-Ibraheem Akram
Department of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan.
Department of Nuclear Medicine,, Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
Nucl Med Mol Imaging. 2020 Aug;54(4):199-203. doi: 10.1007/s13139-020-00650-x. Epub 2020 Jul 6.
Non-ossifying fibroma (NOF) is a common benign bone tumor with a high probability of occurrence in children and adolescents. It is commonly seen in the metaphysis of long bones, eccentrically located, and can coexist with other malignant tumors such as neuroendocrine tumors (NET). To date, plain radiographs play a major role in the diagnosis of these benign bone tumors. Herein, we report the case of a 13-year-old male patient who was diagnosed with pulmonary NET and underwent right lung lobectomy for a hilar mass which later revealed a well-differentiated NET. The follow-up Ga DOTA-TOC PET/CT showed a focal somatostatin receptor expression in the left distal femur, with corresponding CT component findings of a well-defined osteolytic bone lesion located within the medial aspect of the left distal femoral metaphysis, strongly indicative of NOF. To the best of our knowledge, this is the first reported case of such an occurrence.
非骨化性纤维瘤（NOF）是一种常见的良性骨肿瘤，在儿童和青少年中发病概率较高。它常见于长骨的干骺端，呈偏心性分布，并且可能与其他恶性肿瘤如神经内分泌肿瘤（NET）共存。迄今为止，X线平片在这些良性骨肿瘤的诊断中发挥着主要作用。在此，我们报告一例13岁男性患者，该患者被诊断为肺NET，并因肺门肿块接受了右肺叶切除术，术后发现为高分化NET。随访的镓标记奥曲肽PET/CT显示左股骨远端有局灶性生长抑素受体表达，相应的CT表现为左股骨远端干骺端内侧有一个边界清晰的溶骨性骨病变，强烈提示为NOF。据我们所知，这是首例报道的此类病例。
