Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, 1000 Tirana, Albania.
Infectious Diseases Department, Faculty of Medicine, University of Medicine, Tirana, Rruga e Dibrës, 1005 Tirana, Albania.
Molecules. 2022 Apr 7;27(8):2376. doi: 10.3390/molecules27082376.
Since COVID-19 has affected global public health, there has been an urgency to find a solution to limit both the number of infections, and the aggressiveness of the disease once infected. The main characteristic of this infection is represented by a strong alteration of the immune system which, day by day, increases the risk of mortality, and can lead to a multiorgan dysfunction. Because nutritional profile can influence patient's immunity, we focus our interest on resveratrol, a polyphenolic compound known for its immunomodulating and anti-inflammatory properties. We reviewed all the information concerning the different roles of resveratrol in COVID-19 pathophysiology using PubMed and Scopus as the main databases. Interestingly, we find out that resveratrol may exert its role through different mechanisms. In fact, it has antiviral activity inhibiting virus entrance in cells and viral replication. Resveratrol also improves autophagy and decreases pro-inflammatory agents expression acting as an anti-inflammatory agent. It regulates immune cell response and pro-inflammatory cytokines and prevents the onset of thrombotic events that usually occur in COVID-19 patients. Since resveratrol acts through different mechanisms, the effect could be enhanced, making a totally natural agent particularly effective as an adjuvant in anti COVID-19 therapy.
自 COVID-19 影响全球公共卫生以来，迫切需要寻找一种解决方案，以限制感染人数和感染后疾病的侵袭性。这种感染的主要特征是免疫系统的强烈改变，随着时间的推移，增加了死亡率的风险，并可能导致多器官功能障碍。由于营养状况会影响患者的免疫力，我们将兴趣集中在白藜芦醇上，这是一种具有免疫调节和抗炎特性的多酚化合物。我们使用 PubMed 和 Scopus 作为主要数据库，查阅了有关白藜芦醇在 COVID-19 病理生理学中不同作用的所有信息。有趣的是，我们发现白藜芦醇可能通过不同的机制发挥作用。事实上，它具有抗病毒活性，可抑制病毒进入细胞和病毒复制。白藜芦醇还通过改善自噬和减少促炎剂的表达来发挥抗炎作用。它调节免疫细胞反应和促炎细胞因子，并防止 COVID-19 患者中通常发生的血栓事件的发生。由于白藜芦醇通过不同的机制发挥作用，其效果可能会增强，使这种完全天然的药物作为 COVID-19 治疗的辅助药物特别有效。
