Aucoin Monique, Cooley Kieran, Saunders Paul Richard, Carè Jenny, Anheyer Dennis, Medina Daen N, Cardozo Valentina, Remy Daniella, Hannan Nicole, Garber Anna
Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada.
Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, New South Wales, Australia.
Adv Integr Med. 2020 Dec;7(4):203-217. doi: 10.1016/j.aimed.2020.07.004. Epub 2020 Aug 1.
Current evidence suggests that supplementation may decrease the duration and severity of acute respiratory tract infections; however, no studies using in the prevention or treatment of conditions similar to COVID-19 have been identified. Few adverse events were reported, suggesting that this herbal therapy is reasonably safe. Because can increase immune function, there is a concern that it could worsen over-activation of the immune system in cytokine storm; however, clinical trials show that decreases levels of immune molecules involved in cytokine storm.
supplementation may assist with the symptoms of acute respiratory infections (ARI) and the common cold, particularly when administered at the first sign of infection; however, no studies using in the prevention or treatment of conditions similar to COVID-19 have been identified. Previous studies have reported that may decrease the severity and/or duration of ARI when taken at the onset of symptoms. The studies reporting benefit used or a combination of and containing standardized amounts of active constituents.Few adverse events from the use of were reported, suggesting that this herbal therapy is reasonably safe. No human trials could be located reporting evidence of cytokine storm when was used for up to 4 months.When assessing all human trials which reported changes in cytokine levels in response to supplementation, the results were largely consistent with a decrease in the pro-inflammatory cytokines that play a role in the progression of cytokine storm and Acute Respiratory Distress Syndrome (ARDS), factors that play a significant role in the death of COVID-19 patients. While there is currently no research on the therapeutic effects of in the management of cytokine storm, this evidence suggests that further research is warranted.
目前的证据表明，[某种物质]补充剂可能会缩短急性呼吸道感染的持续时间并减轻其严重程度；然而，尚未发现有使用[某种物质]预防或治疗类似于COVID-19病症的研究。报告的不良事件很少，表明这种草药疗法相当安全。由于[某种物质]可以增强免疫功能，有人担心它可能会使细胞因子风暴中免疫系统的过度激活恶化；然而，临床试验表明[某种物质]会降低参与细胞因子风暴的免疫分子水平。
[某种物质]补充剂可能有助于缓解急性呼吸道感染（ARI）和普通感冒的症状，尤其是在感染的最初迹象出现时给药；然而，尚未发现有使用[某种物质]预防或治疗类似于COVID-19病症的研究。先前的研究报告称，在症状出现时服用[某种物质]可能会降低ARI的严重程度和/或持续时间。报告有疗效的研究使用了[某种物质]或含有标准化活性成分量的[某种物质]与[另一种物质]的组合。使用[某种物质]报告的不良事件很少，表明这种草药疗法相当安全。未找到使用[某种物质]长达4个月的人体试验报告细胞因子风暴证据的研究。在评估所有报告补充[某种物质]后细胞因子水平变化的人体试验时，结果在很大程度上与在细胞因子风暴和急性呼吸窘迫综合征（ARDS）进展中起作用的促炎细胞因子减少一致，而这些因素在COVID-19患者死亡中起重要作用。虽然目前尚无关于[某种物质]在治疗细胞因子风暴方面疗效的研究，但这一证据表明有必要进行进一步研究。
