Fan Hengwei, Yu Xiaqing, Fu Xiaohui, Zhu Hengmei, Lv Zhongwei, Yi Wanwan, Zhang Qian
Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital, Navy Medical University (Second Military Medical University), Shanghai, China.
Department of Infection medicine, the Guanggu District of Hubei Province Maternal and Child Health Hospital, Wuhan, Hubei, China.
J Int Med Res. 2020 Aug;48(8):300060520949067. doi: 10.1177/0300060520949067.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test is currently the gold standard for diagnosing coronavirus disease 2019 (COVID-19). This disease requires high-quality viral nucleic acid tests, and selecting the type of specimen from patients, who are at different disease stages, to use in the nucleic acid test is challenging. This article reports in detail the diagnosis and treatment process for two patients with confirmed COVID-19 and analyzes the results of the SARS-CoV-2 nucleic acid tests that were used for different types of specimens (sputum from deep cough, nasopharyngeal swab, and feces). The nucleic acid testing results of sputum from deep cough showed the best performance for positive detection. Our findings provide a reference for selecting the most suitable specimen for the clinical diagnosis of COVID-19 and improving the positive detection rate.
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）核酸检测目前是诊断2019冠状病毒病（COVID-19）的金标准。这种疾病需要高质量的病毒核酸检测，而从处于不同疾病阶段的患者中选择用于核酸检测的标本类型具有挑战性。本文详细报告了两名COVID-19确诊患者的诊断和治疗过程，并分析了针对不同类型标本（深咳痰液、鼻咽拭子和粪便）进行的SARS-CoV-2核酸检测结果。深咳痰液的核酸检测结果显示出最佳的阳性检测性能。我们的研究结果为选择最适合COVID-19临床诊断的标本以及提高阳性检测率提供了参考。
