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一名儿童登革出血热合并糖尿病酮症酸中毒的病例报告:临床管理中的挑战

A case report of dengue hemorrhagic fever complicated with diabetic ketoacidosis in a child: challenges in clinical management.

作者信息

Thadchanamoorthy V, Dayasiri Kavinda

机构信息

Faculty of Health Care Sciences, Eastern University, Batticaloa, Sri Lanka.

Base Hospital, Mahaoya, Sri Lanka.

出版信息

BMC Pediatr. 2020 Aug 26;20(1):403. doi: 10.1186/s12887-020-02300-9.

Abstract

BACKGROUND

Diabetic ketoacidosis (DKA) is a common presentation of type 1 diabetes mellitus (T1DM) precipitated by various bacterial and viral infections. Dengue infection is no exception for this and can be a precipitating factor for DKA. The presentation of DKA with dengue haemorrhagic fever (DHF) has been reported in adults. However, it is very rarely observed in children.

CASE PRESENTATION

We present the case of a paediatric patient who was previously healthy and subsequently, developed polyuria (above 3 ml/kg/hour), irritability and high blood glucose (724 mg/dl) during the critical phase of DHF. DKA was diagnosed with DHF and managed successfully with insulin and intravenous fluids. He recovered without complications and discharged home with follow up being arranged at the endocrinology clinic.

CONCLUSIONS

When both DHF and DKA present together in a patient, meticulous monitoring of glycaemic control as well as fluid management is required to reduce the potential risk for severe complications of both conditions. Since there are no similar paediatric case reported in the literature, this case report might inspire paediatricians to anticipate the possibility of DKA in children with DHF.

摘要

背景

糖尿病酮症酸中毒(DKA)是1型糖尿病(T1DM)的常见表现,由各种细菌和病毒感染诱发。登革热感染也不例外,可成为DKA的诱发因素。成人中已有DKA合并登革出血热(DHF)的病例报道。然而,在儿童中却极为罕见。

病例报告

我们报告一例儿科患者,该患儿此前身体健康,随后在DHF的关键阶段出现多尿(超过3毫升/千克/小时)、烦躁不安及高血糖(724毫克/分升)。该患儿被诊断为DKA合并DHF,并通过胰岛素和静脉补液成功治疗。他康复后未出现并发症,出院时安排在内分泌科门诊进行随访。

结论

当患者同时出现DHF和DKA时,需要对血糖控制和液体管理进行细致监测,以降低两种疾病严重并发症的潜在风险。由于文献中未报道过类似的儿科病例,本病例报告可能会促使儿科医生考虑DHF患儿发生DKA的可能性。

相似文献

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Dengue fever.登革热
BMJ. 2015 Sep 15;351:h4661. doi: 10.1136/bmj.h4661.
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Dengue viral infections.登革病毒感染
Postgrad Med J. 2004 Oct;80(948):588-601. doi: 10.1136/pgmj.2004.019638.

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