School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.
School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA, 30332, USA.
Macromol Biosci. 2020 Nov;20(11):e2000211. doi: 10.1002/mabi.202000211. Epub 2020 Aug 26.
Organic electrochemical transistors that employ polymeric mixed conductors as their active channels are one of the most prominent biosensor platforms because of their signal amplification capability, low fabrication cost, mechanical flexibility, and various properties tunable through molecular design. For application to biomedical devices, polymeric mixed conductors should fulfill several requirements, such as excellent conductivities of both holes/electrons and ions, long-term operation stability, and decent biocompatibility. However, trade-offs may exist, for instance, one between ionic conduction and overall device stability. In this report, the fundamental understanding of polymeric mixed conductors, the recent advance in enhancing their ionic and electrical conductivity, and their practical applications as biosensors based on organic electrochemical transistors are reviewed. Finally, key strategies are suggested for developing novel polymeric mixed conductors that may exceed the trade-off between device performance and stability.
采用聚合物混合导体作为活性通道的有机电化学晶体管是最突出的生物传感器平台之一，因为它们具有信号放大能力、低成本制造、机械灵活性以及通过分子设计可调的各种性质。为了应用于生物医学设备，聚合物混合导体应该满足几个要求，例如，空穴/电子和离子的优异导电性、长期运行稳定性和良好的生物相容性。然而，可能存在权衡，例如，离子传导和整体器件稳定性之间的权衡。在本报告中，综述了聚合物混合导体的基本原理、提高其离子和电导率的最新进展，以及它们作为基于有机电化学晶体管的生物传感器的实际应用。最后，提出了开发可能超越器件性能和稳定性之间权衡的新型聚合物混合导体的关键策略。
