Department of Oral Medicine and Pathology Faculty of Dentistry, National and Kapodistrian University of Athens 2 Thivon Street, 11527 Athens, Greece
Med Oral Patol Oral Cir Bucal. 2021 Jan 1;26(1):e36-e42. doi: 10.4317/medoral.23933.
To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient's age and gender and tumor's site and size may raise the suspicion of neoplasm.
Retrospective analysis was performed on upper or lower labial mucosal tumors, histopathologically diagnosed between 2009-2018. The diagnostic categories developmental/reactive tumors, benign and malignant neoplasms were associated with patient's age and gender and tumor's site and size; clinical-pathological diagnosis agreement was, also, evaluated.
Overall, 1000 (95.7%) developmental/reactive tumors, 35 (3.3%) benign and 10 (1%) malignant neoplasms were found. Upper/lower lip tumor ratio was 0.14:1. The diagnostic category was significantly associated with age (p<0.0001), site (p<0.0001) and diameter (p<0.0001). Age ≥60 years, tumor's location on the upper lip and diameter >1cm were independent predictors for neoplasms. Patients presenting 2 or 3 of these variables were 20.2 times (p < 0.0001) or 33.6 times (p < 0.0001), respectively, more likely to have a neoplasm. Complete/partial agreement between clinical and pathological diagnosis was seen in 96.3% of the cases.
Most lip tumors involve the lower lip and are reactive, but upper lip tumors measuring >1cm in patients≥60 years have significantly higher probability to be neoplasms.
为了调查上、下唇黏膜局限性黏膜肿胀的相对频率，临床病理诊断的一致性，以及患者的年龄和性别、肿瘤的部位和大小是否可能提示肿瘤。
对 2009-2018 年间组织病理学诊断为上、下唇黏膜肿瘤的患者进行回顾性分析。诊断类别为发育/反应性肿瘤、良性和恶性肿瘤，与患者的年龄和性别、肿瘤的部位和大小有关；还评估了临床病理诊断的一致性。
共发现 1000 例（95.7%）发育/反应性肿瘤、35 例（3.3%）良性和 10 例（1%）恶性肿瘤。上/下唇肿瘤比例为 0.14:1。诊断类别与年龄（p<0.0001）、部位（p<0.0001）和直径（p<0.0001）显著相关。年龄≥60 岁、肿瘤位于上唇和直径>1cm 是肿瘤的独立预测因素。有 2 个或 3 个这些变量的患者患有肿瘤的可能性分别是 20.2 倍（p<0.0001）或 33.6 倍（p<0.0001）。临床和病理诊断的完全/部分一致率为 96.3%。
大多数唇肿瘤累及下唇，为反应性，但≥60 岁的患者中直径>1cm 的上唇肿瘤发生肿瘤的可能性显著增加。
