State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, Jiangsu 210096, China.
Biomater Sci. 2021 Jan 26;9(2):315-327. doi: 10.1039/d0bm01020k.
Owing to their superior loading capacity and biocompatibility, imaging agent-conjugated (or encapsulated) peptide-based supramolecular hydrogels are capable of imaging in vivo biological events with enhanced signals. Notably, by rational design of the hydrogelators, the hydrogelation process can "smartly" occur on the pathological site (or region of interest), rendering precise and sensitive bioimaging of the disease (or event) in vivo. Considering their importance in disease diagnosis, herein, we provide a review on the recent advances in peptide-based supramolecular hydrogels for bioimaging applications. Besides, we provide an outlook on the challenges (or chances) for these types of biomaterials in the field of bioimaging.
由于其优越的载药能力和生物相容性，与成像剂偶联（或封装）的基于肽的超分子水凝胶能够以增强的信号进行体内生物事件的成像。值得注意的是，通过合理设计水凝胶剂，水凝胶化过程可以“智能地”在病理部位（或感兴趣区域）发生，从而对体内疾病（或事件）进行精确和敏感的生物成像。鉴于它们在疾病诊断中的重要性，本文综述了用于生物成像应用的基于肽的超分子水凝胶的最新进展。此外，我们还展望了这类生物材料在生物成像领域的挑战（或机遇）。
