College of Animal Science, Zhejiang University, Key Laboratory of animal feed and nutrition of Zhejiang Province, Hangzhou, China.
Metallomics. 2020 Oct 21;12(10):1494-1507. doi: 10.1039/d0mt00149j.
Iron plays an essential role in preventing iron deficiency anemia and ensuring the healthy growth of animals. The special physiological condition of piglets is the main cause of iron deficiency. Iron metabolism in the intestine is the basis for understanding the effects of iron on the health of piglets. In order to scientifically evaluate dietary iron supplementation doses, it is necessary to recognize the effects of iron deficiency and iron overload on piglet intestinal health. Besides, iron as a cofactor is essential for the growth of microorganisms, and microorganisms compete with the host to absorb iron. Under the stress of iron deficiency and iron overload, various control schemes (such as precise nutrition, element balance, elimination of oxidation, etc.) are effective measures to eliminate adverse effects. In this review, we comprehensively review recent findings on the effects of iron deficiency and iron overload on intestinal health. This review will provide a rational design strategy to achieve a reasonable iron supplement, which will guide the use of iron in animal husbandry.
铁在预防缺铁性贫血和确保动物健康生长方面起着至关重要的作用。仔猪的特殊生理状况是导致缺铁的主要原因。肠道中的铁代谢是理解铁对仔猪健康影响的基础。为了科学评估膳食铁补充剂量，有必要认识到缺铁和铁过载对仔猪肠道健康的影响。此外，铁作为辅助因子对微生物的生长至关重要，微生物与宿主竞争吸收铁。在缺铁和铁过载的压力下，各种控制方案（如精确营养、元素平衡、消除氧化等）是消除不良影响的有效措施。在这篇综述中，我们全面回顾了铁缺乏和铁过载对肠道健康的影响的最新发现。本综述将为实现合理铁补充提供合理的设计策略，指导畜牧业中铁的使用。
