深海霉素2通过一种不依赖蛋白激酶C和组蛋白去乙酰化酶的机制重新激活潜伏的HIV-1。
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
作者信息
León Brian, Navarro Gabriel, Dickey Bailey J, Stepan George, Tsai Angela, Jones Gregg S, Morales Monica E, Barnes Tiffany, Ahmadyar Shekeba, Tsiang Manuel, Geleziunas Romas, Cihlar Tomas, Pagratis Nikos, Tian Yang, Yu Helen, Linington Roger G
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Cruz , 1156 High Street, Santa Cruz, California 95064, United States.
出版信息
Org Lett. 2015 Jan 16;17(2):262-5. doi: 10.1021/ol503349y. Epub 2015 Jan 5.
Abstract
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.
摘要
对一个海洋天然产物文库进行筛选，得到了三种新的含四内酯酸的聚酮化合物类阿比西尼亚霉素家族类似物，并确定阿比西尼亚霉素2为潜伏性HIV病毒的选择性再激活剂。对这种新型潜伏性HIV再激活剂的作用模式进行研究表明，与现有再激活剂相比，它通过一种不同的机制发挥作用，并且在一部分原发性患者细胞系中能够有效地激活潜伏病毒。
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