Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Oral Dis. 2022 Jan;28(1):33-43. doi: 10.1111/odi.13617. Epub 2020 Sep 18.
The present study aimed to summarize and update the evidence regarding the association between periodontitis and psoriasis.
The present systematic review was conducted under the guidelines of Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) and was recorded in the PROSPERO database, under registration number CRD42017063799. Three databases (MEDLINE, Embase, and Cochrane Library) were searched up to March 2020. Case-control or cohort studies assessing the association between periodontitis and psoriasis were identified. Quantitative synthesis was conducted with meta-analysis.
A total of 13 studies (11 case-control and two cohort studies) assessing the association between periodontitis and psoriasis were included. Of these 13 articles, 9 showed the prevalence of periodontitis or psoriasis. Therefore, meta-analyses were conducted with data retrieved from the nine studies included. Pooled effect estimate for nine studies showed that patients with periodontitis associated with a higher risk of psoriasis with a pooled OR of 2.87 (95% CI, 1.75-4.69).
This systematic review demonstrated a positive association between periodontitis and psoriasis; however, a causal relationship cannot be established. Due to the weak evidence, caution should be taken when interpreting the results regarding periodontal parameters. Well-designed prospective studies are necessary to evaluate interactions between both diseases.
本研究旨在总结和更新牙周炎与银屑病之间关联的证据。
本系统评价根据系统评价和荟萃分析的透明报告（PRISMA）指南进行，并在 PROSPERO 数据库中记录，注册号为 CRD42017063799。截至 2020 年 3 月，检索了 MEDLINE、Embase 和 Cochrane Library 三个数据库。确定了评估牙周炎与银屑病之间关联的病例对照或队列研究。采用荟萃分析进行定量综合。
共纳入 13 项研究（11 项病例对照研究和 2 项队列研究）评估牙周炎与银屑病之间的关联。在这 13 篇文章中，有 9 篇显示了牙周炎或银屑病的患病率。因此，对纳入的 9 项研究进行了荟萃分析。从纳入的九项研究中提取的数据进行汇总效应估计显示，患有牙周炎的患者患银屑病的风险更高，合并 OR 为 2.87（95%CI，1.75-4.69）。
本系统评价表明牙周炎与银屑病之间存在正相关关系；然而，不能确定因果关系。由于证据较弱，在解释与牙周参数相关的结果时应谨慎。需要进行精心设计的前瞻性研究来评估这两种疾病之间的相互作用。
