Université Côte d'Azur, CNRS, Institut de Chimie de Nice, Parc Valrose, 06108, Nice cedex 2, France.
ChemSusChem. 2020 Nov 6;13(21):5600-5610. doi: 10.1002/cssc.202001661. Epub 2020 Sep 11.
White biotechnology has emerged in biochemical manufacturing processes to deliver perfumery ingredients satisfying interests of the society for natural, eco-responsible, and sustainable materials. As a result, an intense R&D activity has taken place on these subjects, resulting in both scientific publications and patent applications reporting combinations of state-of-the-art approaches in biocatalysis, metabolic engineering, synthetic biology, biosynthesis elucidation, gene edition and cloning, and analytical chemistry. In this Minireview, a smelly selection of novel biotechnological processes and ingredients from a scientific articles and patents survey covering the last 6 years is presented and analysed in terms of chemistry, sustainability and naturality. Classification has been made between metabolic engineering on one side, allowing either biotechnological synthesis of essential oil surrogates or single molecule ingredients, and on the other side the optimisation of properties of natural complex substances by specific and selective enzymatic modifications of their chemical composition.
白色生物技术已在生化制造工艺中崭露头角，为满足社会对天然、生态负责和可持续材料的兴趣而提供香水成分。因此，针对这些主题开展了激烈的研发活动，导致科学出版物和专利申请报告了生物催化、代谢工程、合成生物学、生物合成阐明、基因编辑和克隆以及分析化学等最先进方法的组合。在这篇综述中，从涵盖过去 6 年的科学文章和专利调查中选择了一些新颖的生物技术过程和成分进行了臭味分析，并从化学、可持续性和自然性方面进行了分析。分类方法是一方面进行代谢工程，允许生物技术合成精油替代品或单一分子成分，另一方面通过对天然复杂物质化学成分进行特定和选择性的酶修饰来优化其性质。
