Hanoi Medical University, Hanoi, Viet Nam.
School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Hanoi, Viet Nam.
Asian Pac J Cancer Prev. 2020 Aug 1;21(8):2217-2223. doi: 10.31557/APJCP.2020.21.8.2217.
The aim was to examine the association between heterocyclic amines 2-amino-1-methyl-6-phenylimidazo pyridine (PhIP) and the risk of colorectal cancer (CRC) in Viet Nam.
We performed a case-control study for 512 colorectal cancer patients with the histopathological confirmation and 1,096 hospital controls. We collected information on lifestyle, diet, and cooking methods from participants by trained interviewers using the validated questionnaires. We used data of PhIP concentration in cooked beef analyzed by the LC/MS/MS and cooking questionnaire to estimate the daily intake of PhIP. We divided the estimated amount of PhIP (ng/person/day) into three levels of non-intake (the reference), medium, and high to estimate the Odds ratio and 95% confidence interval (OR, 95%CI).
The median intake of PhIP (ng/person/day) was 18ng and 102.8ng for medium and high PhIP intake, respectively. There was a significant association between PhIP intake and the risk of colorectal cancer. The adjusted OR (95%C), high intake vs. non-intake, were 4.89 (3.03, 7.89), p_trend.
本研究旨在探讨杂环胺 2-氨基-1-甲基-6-苯基咪唑并吡啶（PhIP）与越南结直肠癌（CRC）风险之间的关联。
我们进行了一项病例对照研究，纳入 512 名经组织病理学证实的结直肠癌患者作为病例组，以及 1096 名医院对照作为对照组。我们通过经过培训的调查员使用经过验证的问卷，从参与者那里收集生活方式、饮食和烹饪方法相关的信息。我们使用 LC/MS/MS 分析的烹饪牛肉中 PhIP 浓度数据和烹饪问卷来估计 PhIP 的日摄入量。我们将估计的 PhIP 量（ng/人/天）分为非摄入（参考）、中、高三个水平，以估计比值比和 95%置信区间（OR，95%CI）。
PhIP 摄入量的中位数（ng/人/天）分别为 18ng 和 102.8ng ，代表中、高 PhIP 摄入量。PhIP 摄入与结直肠癌风险之间存在显著关联。调整后的 OR（95%CI），高摄入量与非摄入量相比，分别为 4.89（3.03，7.89），p_trend。
