Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, University of the Western Cape, Cape Town 7535, South Africa.
Viruses. 2020 Aug 26;12(9):937. doi: 10.3390/v12090937.
Seven human coronaviruses (hCoVs) are known to infect humans. The most recent one, SARS-CoV-2, was isolated and identified in January 2020 from a patient presenting with severe respiratory illness in Wuhan, China. Even though viral coinfections have the potential to influence the resultant disease pattern in the host, very few studies have looked at the disease outcomes in patients infected with both HIV and hCoVs. Groups are now reporting that even though HIV-positive patients can be infected with hCoVs, the likelihood of developing severe CoV-related diseases in these patients is often similar to what is seen in the general population. This review aimed to summarize the current knowledge of coinfections reported for HIV and hCoVs. Moreover, based on the available data, this review aimed to theorize why HIV-positive patients do not frequently develop severe CoV-related diseases.
已知有七种人类冠状病毒（hCoV）可感染人类。最近的一种是 SARS-CoV-2，它于 2020 年 1 月在中国武汉从一名出现严重呼吸道疾病的患者中分离和鉴定出来。尽管病毒合并感染有可能影响宿主的疾病模式，但很少有研究关注同时感染 HIV 和 hCoV 的患者的疾病结局。现在有研究组报告称，尽管 HIV 阳性患者可能感染 hCoV，但这些患者发生严重 CoV 相关疾病的可能性通常与普通人群相似。本综述旨在总结目前已报道的 HIV 和 hCoV 合并感染的相关知识。此外，根据现有数据，本综述旨在推测为什么 HIV 阳性患者不常发生严重的 CoV 相关疾病。
