Mass Spectrometry Centre, LAQV REQUIMTE, Department of Chemistry, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal.
Centre for Environmental and Marine Studies, CESAM, ECOMARE, Department of Biology, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal.
Molecules. 2020 Aug 26;25(17):3883. doi: 10.3390/molecules25173883.
Marine edible macroalgae have functional proprieties that might improve human health and wellbeing. Lipids represent a minor fraction of macroalgae, yet with major interest as main carriers of omega 3 polyunsaturated fatty acids and intrinsic bioactive properties. In this study, we used lipid extracts from the green macroalgae and ; the red and and the brown , produced in a land-based integrated multitrophic aquaculture (IMTA) system. We determined the lipid quality indices based on their fatty acid profiles and their bioactivities as putative antioxidant, anti-inflammatory and antiproliferative agents. The results reveal to be species-specific, namely displayed the lowest atherogenicity and thrombogenicity indices. and lipid extracts displayed the lowest inhibitory concentration in the free radical scavenging antioxidant assays. and inhibited COX-2 activity by up to 80%, while and extracts showed the highest cytotoxic potential in the MDA-MB-231 breast cancer cells. This work enhances the valorization of macroalgae as functional foods and promising ingredients for sustainable and healthy diets and fosters new applications of high-valued algal biomass, in a species-specific context.
海洋食用大型藻类具有改善人类健康和福祉的功能特性。脂质是大型藻类的一小部分，但作为 ω-3 多不饱和脂肪酸的主要载体和内在生物活性物质，具有重要的研究意义。在这项研究中，我们使用了陆地综合多营养水产养殖（IMTA）系统中生产的绿色大型藻类 和 、红色大型藻类 和 以及棕色大型藻类 的脂质提取物。我们根据其脂肪酸谱和作为潜在抗氧化剂、抗炎和抗增殖剂的生物活性来确定脂质质量指数。结果表明这些质量指数具有物种特异性，即 显示出最低的动脉粥样硬化和血栓形成指数。 和 的脂质提取物在自由基清除抗氧化测定中显示出最低的抑制浓度。 和 对 COX-2 活性的抑制作用高达 80%，而 和 提取物在 MDA-MB-231 乳腺癌细胞中显示出最高的细胞毒性潜力。这项工作增强了大型藻类作为功能性食品的价值，以及作为可持续和健康饮食的有前途的成分，并在特定物种的背景下促进了高价值藻类生物质的新应用。
