Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan.
Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, 102-0083, Japan.
Commun Biol. 2020 Aug 28;3(1):473. doi: 10.1038/s42003-020-01209-4.
The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6/n-3 diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6/n-3 diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6/n-3 diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring's pattern for consuming highly palatable foods.
肥胖症的发病率不断上升及其对社会的影响，使得我们有必要加强基础动物研究，以了解为什么由于最近的全球环境变化，习惯性摄入高美味食品的情况有所增加。在这里，我们报告说，食用富含ω-6（n-6）多不饱和脂肪酸（PUFA）和低ω-3（n-3）PUFA（n-6/n-3 饮食）的饮食的怀孕老鼠，其 n-6/n-3 比例约为 120，通过上调中脑多巴胺能系统诱导后代的享乐性消费。我们发现，暴露于 n-6/n-3 饮食会通过增加中脑边缘多巴胺释放来特异性地增加对美味食物的消费。此外，神经发育分析表明，这种诱导的享乐性消费是在胚胎发生期间编程的，因为在子宫内接触 n-6/n-3 饮食会增加多巴胺能神经发生。我们的研究结果表明，母体 PUFAs 的消耗会对后代食用高美味食品的模式产生持久影响。
