在埃塞俄比亚东部的哈拉尔，对高血压与血压正常个体的血液学参数进行比较研究。
A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia.
机构信息
Department of Medical Laboratory Science, Collage of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Department of Medical Laboratory Science, Collage of Health and Medical Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
出版信息
PLoS One. 2021 Dec 7;16(12):e0260751. doi: 10.1371/journal.pone.0260751. eCollection 2021.
BACKGROUND
Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia.
METHODS
A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant's socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman's correlation was used for correlation test. P values less than 0.05 was considered as statistically significant.
RESULT
102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010).
CONCLUSION
The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.
背景
高血压是主要的公共卫生问题，可导致心血管疾病。它与血液学参数的改变有关，这些改变可能导致终末器官损伤。因此，本研究旨在比较埃塞俄比亚东部哈拉尔市高血压和正常血压成人组之间的血液学参数。
方法
这是一项 2020 年 1 月至 3 月在哈拉尔的 Jugel 和 Hiwotfana 专科医院进行的比较性横断面研究。采用便利抽样技术，从这两家医院招募了 102 名高血压患者和 102 名健康献血者。采用经过预测试的结构问卷收集参与者的社会人口学和临床信息。使用贝克曼库尔特 DxH500 分析仪采集血样进行全血细胞计数。将数据输入并使用 SPSS 版本 23 进行分析。采用独立 t 检验和曼-惠特尼 U 检验比较组间差异。采用斯皮尔曼相关检验进行相关性检验。P 值<0.05 被认为具有统计学意义。
结果
本研究共纳入 102 名高血压患者和 102 名健康对照者。与健康对照组相比，高血压组的白细胞（WBC）计数、血红蛋白（Hgb）、血细胞比容（HCT）、红细胞分布宽度（RDW）和平均血小板体积（MPV）中位数（± IQR）更高。此外，RBC（红细胞）计数、HCT 和 RDW 与收缩压和舒张压呈显著正相关。WBC 计数和 RDW 与体重指数（BMI）呈显著正相关。血小板（PLT）计数与高血压病程呈显著负相关（r = -0.219，P = 0.027），而 MPV 与高血压呈显著正相关（r = 0.255，P = 0.010）。
结论
与健康个体相比，高血压患者的 WBC、Hgb、HCT、RDW 和 MPV 中位数显著升高。因此，评估高血压患者的血液学参数对于预防与血液学异常相关的并发症非常重要。然而，需要进一步的研究来了解高血压相关的血液学参数变化。
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