体育锻炼可能通过SIRT1-FOXO1/3-PINK1-帕金介导的线粒体自噬逆转线粒体功能障碍，从而对阿尔茨海默病产生治疗作用。
Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy.
作者信息
Zhao Na, Xia Jie, Xu Bo
机构信息
Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China; College of Physical Education and Health, East China Normal University, Shanghai 200241, China.
Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China; College of Physical Education and Health, East China Normal University, Shanghai 200241, China.
出版信息
J Sport Health Sci. 2021 Jan;10(1):1-3. doi: 10.1016/j.jshs.2020.08.009. Epub 2020 Aug 28.
• Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease. • Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness. • Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy.
• 体育锻炼能有效预防阿尔茨海默病的进展并降低患该病的风险。
• 体育锻炼通过促进线粒体健康来对抗阿尔茨海默病的发生和发展。
• 体育锻炼可能通过SIRT1-FOXO1/3-PINK1-帕金介导的线粒体自噬逆转线粒体功能障碍，从而对阿尔茨海默病发挥治疗作用。
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