手术治疗原发性先天性青光眼患者饮水试验后的眼压变化

Intraocular Pressure Changes after Water Drinking Test in Surgically Treated Primary Congenital Glaucoma.

作者信息

Razeghinejad Reza, Tajbakhsh Zahra, Masoumpour Masoumeh Beigom, Nowroozzadeh M Hossein

机构信息

Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

J Ophthalmic Vis Res. 2020 Aug 6;15(3):318-325. doi: 10.18502/jovr.v15i3.7450. eCollection 2020 Jul-Sep.

DOI:10.18502/jovr.v15i3.7450

PMID:32864062

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7431708/

Abstract

PURPOSE

To assess intraocular pressure (IOP) changes after the water drinking test (WDT) in patients with primary congenital glaucoma (PCG).

METHODS

In this prospective interventional study, 20 eyes of 20 patients with PCG were included. All patients had undergone trabeculotomy. Six out of twenty eyes had received a glaucoma drainage device (GDD) implantation. IOP was measured using an air-puff tonometer at baseline, and 15, 30, 45, and 60 min after WDT. The repeated-measures analysis of variance test was used to compare the mean IOPs at different time points.

RESULTS

The mean ( standard deviation) of participants' age was 9.9 2.7 years (range, 6 to 16 years), and 8 (40%) participants were male. The mean IOPs at baseline and 15, 30, 45, and 60 minutes after the WDT were 15.8 3.7, 18.6 3.4, 19.0 3.8, 17.9 3.8, and 16.9 3.5 mmHg, respectively ( 0.001). Pairwise comparisons revealed that the mean IOPs after 15 and 30 min were significantly greater than the baseline IOP ( 0.001 and = 0.002, respectively); however, the difference in mean IOPs after 45 and 60 min were not statistically significant from the baseline IOP. The averages of IOP peak and IOP fluctuation after the WDT were 20.0 3.5 and 4.2 2.9 mmHg, respectively. IOP fluctuation in those who underwent trabeculotomy alone was twice that of those with GDDs, but the difference was not statistically significant (5.0 vs 2.5 mmHg; = 0.08).

CONCLUSION

In patients with PCG, WDT induced significant IOP elevation 15 and 30 min after the test, which returned to pre-test values after 45 min.

摘要

目的

评估原发性先天性青光眼（PCG）患者饮水试验（WDT）后的眼压（IOP）变化。

方法

在这项前瞻性干预研究中，纳入了20例PCG患者的20只眼。所有患者均接受了小梁切开术。20只眼中有6只眼接受了青光眼引流装置（GDD）植入。在基线时以及WDT后15、30、45和60分钟使用气眼压计测量眼压。采用重复测量方差分析来比较不同时间点的平均眼压。

结果

参与者的平均（标准差）年龄为9.9±2.7岁（范围6至16岁），8名（40%）参与者为男性。WDT后基线、15、30、45和60分钟时的平均眼压分别为15.8±3.7、18.6±3.4、19.0±3.8、17.9±3.8和16.9±3.5 mmHg（P<0.001）。两两比较显示，15和30分钟后的平均眼压显著高于基线眼压（分别为P<0.001和P = 0.002）；然而，45和60分钟后的平均眼压与基线眼压的差异无统计学意义。WDT后的眼压峰值和眼压波动平均值分别为20.0±3.5和4.2±2.9 mmHg。单纯接受小梁切开术患者的眼压波动是接受GDD植入患者的两倍，但差异无统计学意义（5.0对2.5 mmHg；P = 0.08）。