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腺病毒与新型冠状病毒(SARS-CoV2)合并感染:一例病例报告。

Adenovirus and novel coronavirus (SARS-Cov2) coinfection: A case report.

作者信息

Motta Juan Camilo, Gómez Carmen Cecilia

机构信息

Internal Medicine Resident, Universidad Del Rosario, Bogotá, Colombia.

Internal Medicine, Fundación Cardioinfantil, Bogotá, Colombia.

出版信息

IDCases. 2020;22:e00936. doi: 10.1016/j.idcr.2020.e00936. Epub 2020 Aug 22.

DOI:10.1016/j.idcr.2020.e00936
PMID:32864341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7443165/
Abstract

SARS-Cov2 coinfection with other respiratory viruses is very rare. Adenovirus coinfection is even more unusual. We report the case of a patient with poorly controlled diabetes, and he was admitted to the emergency department because of severe COVID-19 infection. He had unfavorable prognostic factors such as moderate oxygen impairment, positive D-dimer, increased lactate dehydrogenase and ferritin. Adenovirus was isolated in a respiratory viral panel. He developed acute respiratory distress syndrome and required pronation and neuromuscular relaxation in the intensive care unit. Hydroxychloroquine was administered as suggested by the national guidelines. The symptoms resolved, and hospital discharge was indicated. COVID-19 association with another respiratory virus is related with adverse clinical outcomes, such as shock, ventilatory support requirement and greater lymphopenia and thrombocytopenia.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV2)与其他呼吸道病毒合并感染非常罕见。腺病毒合并感染则更为不寻常。我们报告了一例糖尿病控制不佳的患者,他因严重的2019冠状病毒病(COVID-19)感染而被收入急诊科。他具有不良预后因素,如中度氧损伤、D-二聚体阳性、乳酸脱氢酶和铁蛋白升高。在呼吸道病毒检测中分离出了腺病毒。他发展为急性呼吸窘迫综合征,在重症监护病房需要俯卧位通气和神经肌肉松弛治疗。按照国家指南建议给予了羟氯喹。症状缓解,指示可以出院。COVID-19与另一种呼吸道病毒合并感染与不良临床结局相关,如休克、需要通气支持以及更严重的淋巴细胞减少和血小板减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a6/7473869/84bf2d9cfd15/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a6/7473869/11c47c255d3f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a6/7473869/84bf2d9cfd15/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a6/7473869/11c47c255d3f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a6/7473869/84bf2d9cfd15/gr2.jpg

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Coinfection with SARS-CoV-2 and other respiratory pathogens in patients with COVID-19 in Guangzhou, China.中国广州新冠肺炎患者中SARS-CoV-2与其他呼吸道病原体的合并感染
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