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培养基中异种β2-微球蛋白的H-2依赖性结合

H-2-dependent binding of xenogeneic beta 2-microglobulin from culture media.

作者信息

Kievits F, Boerenkamp W J, Ivanyi P

机构信息

Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.

出版信息

J Immunol. 1988 Jun 15;140(12):4253-5.

PMID:3286770
Abstract

Sera of C57BL/6 mice contained lymphocytotoxic antibodies after injections with syngeneic lymphoblasts. The antibodies were directed against bovine beta 2-microglobulin, a component of the culture medium, and mimicked H-2-specific antibodies by a preferential recognition of target cells expressing certain H-2 Ag. This "polymorphic" reactivity pattern was due to a variable capacity of H-2 molecules associated with bovine beta 2-microglobulin.

摘要

给C57BL/6小鼠注射同基因淋巴细胞后，其血清中含有淋巴细胞毒性抗体。这些抗体针对培养基成分牛β2-微球蛋白，并通过优先识别表达某些H-2抗原的靶细胞来模拟H-2特异性抗体。这种“多态性”反应模式是由于与牛β2-微球蛋白相关的H-2分子的可变能力所致。

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H-2-dependent binding of xenogeneic beta 2-microglobulin from culture media.培养基中异种β2-微球蛋白的H-2依赖性结合
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Association of serum beta 2-microglobulin with H-2 class I heavy chains on the surface of mouse cells in culture.培养的小鼠细胞表面血清β2-微球蛋白与H-2 I类重链的关联。
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Recognition of the beta-2 microglobulin-B molecule by a CTL clone.一个CTL克隆对β2微球蛋白-B分子的识别。
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