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关于光学相干断层扫描血管造影术在白点综合征中的价值的当前文献综述及我们的经验

Review of the Current Literature and Our Experience on the Value of OCT-angiography in White Dot Syndromes.

作者信息

Mebsout-Pallado Céline, Orès Raphaëlle, Terrada Céline, Dansingani Kunal K, Chhablani Jay, Eller Andrew W, Martel Joseph N, Anetakis Alexander, Harwick Jean C, Waxman Evan L, Gallagher Denise S, Prensky Colin, Indermill Chad, Sedira Neila, Héron Emmanuel, Paques Michel, Brignole-Baudouin Françoise, Bodaghi Bahram, Sahel José-Alain, Gaudric Alain, Mrejen Sarah, Errera Marie-Hélène

机构信息

DHU Sight Restore, Centre Hospitalier National Des Quinze-Vingts, Paris, France.

Department of Ophthalmology, Lariboisière Hospital, Université Paris Diderot, Paris, France.

出版信息

Ocul Immunol Inflamm. 2022 Feb 17;30(2):364-378. doi: 10.1080/09273948.2020.1837185. Epub 2021 Feb 22.

Abstract

PURPOSE

To describe the application of OCT-A in various posterior uveitis disorders in our experience and to compare it with the available literature.

METHODS

Eighteen eyes with the diagnoses of multifocal choroiditis (MFC), multifocal placoid pigment epitheliopathy (APMPPE), multiple evanescent white dot syndrome (MEWDS), tuberculous serpiginous-like choroiditis (SLC), serpiginous choroiditis (SC), and birdshot chorioretinopathy (BSCR) were studied.

RESULTS

We found flow void of the choriocapillaris in patients with APMPPE, SC, MFC, BSCR, and in SLC. In contrast, perfusion of the choriocapillaris seemed normal in patients with MEWDS.

CONCLUSIONS

We confirmed that OCT-A contributes new information on the physiopathology of white dot syndromes and inflammatory chorioretinopathies, notably on whether or not the choriocapillaris is involved. Comparing the OCT-A features allowed us to suggest that both APMPPE and SLC might be part of the same spectrum of inflammatory disease with primary involvement at the level of the choriocapillaris and secondary RPE damage.

摘要

目的

根据我们的经验描述光学相干断层扫描血管造影(OCT-A)在各种后葡萄膜炎疾病中的应用,并与现有文献进行比较。

方法

对18只诊断为多灶性脉络膜炎(MFC)、多灶性扁平状色素上皮病变(APMPPE)、多发性一过性白点综合征(MEWDS)、结核性匐行性脉络膜炎(SLC)、匐行性脉络膜炎(SC)和鸟枪弹样脉络膜视网膜病变(BSCR)的眼睛进行了研究。

结果

我们发现APMPPE、SC、MFC、BSCR和SLC患者的脉络膜毛细血管存在血流缺失。相比之下,MEWDS患者的脉络膜毛细血管灌注似乎正常。

结论

我们证实OCT-A为白点综合征和炎性脉络膜视网膜病变的病理生理学提供了新信息,特别是关于脉络膜毛细血管是否受累。通过比较OCT-A特征,我们认为APMPPE和SLC可能是同一谱系炎性疾病的一部分,主要累及脉络膜毛细血管水平并继发视网膜色素上皮损伤。

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