Bampidis Vasileios, Azimonti Giovanna, de Lourdes Bastos Maria, Christensen Henrik, Dusemund Birgit, Kos Durjava Mojca, Kouba Maryline, Ramos Fernando, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Cocconcelli Pier Sandro, Glandorf Boet, Herman Lieve, Maradona Miguel Prieto, Saarela Maria, Anguita Montserrat, Holczknecht Orsolya, Galobart Jaume, Manini Paola, Pettenati Elisa, Pizzo Fabiola, Tarrés-Call Jordi
EFSA J. 2020 Apr 28;18(4):e06074. doi: 10.2903/j.efsa.2020.6074. eCollection 2020 Apr.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of l-valine (≥ 98.0%) produced by fermentation using a genetically modified strain of (KCCM 80159). It is intended to be used in feed for all animal species and categories. Species identity of the production organism KCCM 80159 was confirmed; the strain was sensitive to antibiotics at concentrations below or equal to thresholds specified by EFSA; and no viable cells or its recombinant DNA were detected in the final product. Therefore, the final product does not give raise to any safety concern with regard to the genetic modification of the production strain. The FEEDAP Panel concludes that l-valine produced by KCCM 80159 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species, for the consumer, for the users and for the environment. The product l-valine produced by fermentation using KCCM 80159 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就使用基因改造的**（KCCM 80159）菌株发酵生产的L-缬氨酸（≥98.0%）的安全性和有效性发表科学意见。它拟用于所有动物种类和类别的饲料。生产菌株KCCM 80159的物种身份已得到确认；该菌株对低于或等于欧洲食品安全局规定阈值浓度的抗生素敏感；且在最终产品中未检测到活细胞或其重组DNA。因此，最终产品不会引发对生产菌株基因改造的任何安全担忧。FEEDAP小组得出结论，当根据目标物种的营养需求向日粮中适量添加时，KCCM 80159生产的L-缬氨酸对目标物种、消费者、使用者和环境而言是安全的。使用KCCM 80159发酵生产的产品L-缬氨酸被视为非反刍动物营养中必需氨基酸L-缬氨酸的有效来源。为使补充的L-缬氨酸在反刍动物中与在非反刍动物物种中一样有效，需要对其进行保护以防在瘤胃中降解。
