Yu Zi-Yan, Huang Ting, Lu Lu, Qu Bo
Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang 110005, Liaoning Province, China.
Department of Cataract, Aier Mega Ophthalmic Hospital of Chongqing, Chongqing 400060, China.
World J Clin Cases. 2020 Aug 6;8(15):3249-3258. doi: 10.12998/wjcc.v8.i15.3249.
Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision. The variable clinical manifestations may result in differential diagnostic difficulties. The early screening and diagnosis of glaucoma are currently experiencing a demand for anterior segment analysis tools that can gather more information with one short measurement. Therefore, we analyzed the agreement, difference, and correlation of chamber angle parameters such as angel opening distance at 500 μm (AOD500) and trabeculo-iris space area at 500 μm (TISA500) measured by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM).
To compare the differences, correlation, and agreement in measuring AOD500 and TISA500 by AS-OCT and UBM.
Both AS-OCT and UBM were performed to measure AOD500 and TISA500 in 45 subjects (72 eyes). All subjects without glaucoma were collected from October 2015 to August 2016 at the Ophthalmology Department of the Fourth Affiliated Hospital of China Medical University. Data of the two groups (AOD500 and TISA500) were compared by nonparametric tests. Pearson correlative analysis and Bland-Altman analysis were used to compare the correlation and agreement.
There were no significant differences between AS-OCT and UBM in measuring AOD500 (1 = 0.110, 2 = 0.633, 3 = 0.078, and 4 = 0.474) and TISA500 (1 = 0.584, 2 = 0.889, 3 = 0.297, and 4 = 0.550) of the four quadrants of the anterior chamber angle. There was a high correlation in measuring AOD500 (1 = 0.562, 2 = 0.671, 3 = 0.635, and 4 = 0.720; < 0.001) and TISA500 (1 = 0.584, 2 = 0.889, 3 = 0.297, and 4 = 0.550; < 0.001). There was a good agreement in measuring AOD500 and TISA500 by the two modalities.
There is a high correlation and agreement between AOD500 and TISA500 measurements by AS-OCT and UBM. They are interchangeable under some circumstances. AS-OCT proves to be a better early screening tool for glaucoma.
青光眼是一种导致视野丧失和视力下降的不可逆性视神经病变。其临床表现多样，可能导致鉴别诊断困难。目前青光眼的早期筛查和诊断需要能够通过一次简短测量收集更多信息的眼前节分析工具。因此，我们分析了通过眼前节光学相干断层扫描（AS-OCT）和超声生物显微镜（UBM）测量的房角参数，如500μm处房角开放距离（AOD500）和500μm处小梁-虹膜间隙面积（TISA500）的一致性、差异及相关性。
比较AS-OCT和UBM测量AOD500和TISA500的差异、相关性及一致性。
对45例受试者（72只眼）进行AS-OCT和UBM检查以测量AOD500和TISA500。所有无青光眼的受试者于2015年10月至2016年8月在中国医科大学附属第四医院眼科收集。两组数据（AOD500和TISA500）通过非参数检验进行比较。采用Pearson相关分析和Bland-Altman分析比较相关性和一致性。
AS-OCT和UBM在测量前房角四个象限的AOD500（1 = 0.110，2 = 0.633，3 = 0.078，4 = 0.474）和TISA500（1 = 0.584，2 = 0.889，3 = 0.297，4 = 0.550）方面无显著差异。在测量AOD500（1 = 0.562，2 = 0.671，3 = 0.635，4 = 0.720；<0.001）和TISA500（1 = 0.584，2 = 0.889，3 = 0.297，4 = 0.550；<0.001）方面存在高度相关性。两种方法在测量AOD500和TISA500方面具有良好的一致性。
AS-OCT和UBM测量AOD500和TISA500之间存在高度相关性和一致性。在某些情况下它们可相互替代。AS-OCT被证明是一种更好的青光眼早期筛查工具。
