Scott Sion, May Helen, Patel Martyn, Wright David J, Bhattacharya Debi
School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK.
Older People's Medicine Department, Norfolk and Norwich University Hospitals NHS Foundation Trust, , Norwich, NR4 7UY, UK.
Age Ageing. 2021 Feb 26;50(2):581-586. doi: 10.1093/ageing/afaa169.
hospital deprescribing trials have demonstrated marginal increases in deprescribing activity that are not sustained beyond the trial period. The hospital deprescribing implementation framework (hDIF) links barriers and enablers of deprescribing in hospital with 44 potential intervention components. This study aimed to support geriatricians and pharmacists to select and characterise hDIF components according to affordability, practicability, effectiveness, acceptability, safety and equity (APEASE) to design a deprescribing intervention in the English hospital setting.
we convened a modified Nominal Group Technique with a panel of nine geriatricians and pharmacists representing five English hospitals. Panel members selected and characterised intervention components from the hDIF based on the APEASE criteria. We set a consensus threshold of 80% agreement per APEASE criterion in order for the intervention component to be included.
the panel selected five intervention components supporting engagement with deprescribing: an organisational action plan to prioritise deprescribing, two training activities to address pharmacists' beliefs about negative deprescribing consequences, restructuring pharmacists' working patterns to facilitate their contribution to deprescribing decisions, and sharing experiences of successfully engaging patients/family in deprescribing conversations to support others to do the same. A sixth component was selected to sustain engagement with deprescribing through measuring and sharing deprescribing activity achieved between teams.
deprescribing interventions targeting geriatricians' and pharmacists' behaviour in the English hospital context should include the six characterised components. A component to sustain deprescribing activity is a notable omission from previously reported deprescribing interventions and may explain their failure to maintain efficacy beyond the short-term trial period.
医院减药试验表明,减药活动仅有少量增加,且在试验期后无法持续。医院减药实施框架(hDIF)将医院减药的障碍和促进因素与44个潜在干预要素联系起来。本研究旨在支持老年医学专家和药剂师根据可承受性、实用性、有效性、可接受性、安全性和公平性(APEASE)来选择和描述hDIF要素,以设计英国医院环境下的减药干预措施。
我们召集了一个经过改良的名义群体技术小组,成员包括来自英国五家医院的九名老年医学专家和药剂师。小组成员根据APEASE标准从hDIF中选择并描述干预要素。我们为每个APEASE标准设定了80%的共识阈值,以便纳入干预要素。
小组选择了五个支持参与减药的干预要素:一项将减药列为优先事项的组织行动计划、两项针对药剂师对减药负面后果看法的培训活动、调整药剂师的工作模式以促进他们对减药决策的贡献,以及分享成功让患者/家属参与减药对话以支持他人效仿的经验。还选择了第六个要素,即通过衡量和分享各团队之间实现的减药活动来维持对减药的参与。
针对英国医院环境中老年医学专家和药剂师行为的减药干预措施应包括这六个已描述的要素。维持减药活动的要素在先前报道的减药干预措施中明显缺失,这可能解释了它们在短期试验期后未能维持疗效的原因。