[胃癌中胃蛋白酶原的免疫形态学研究]
[Immunomorphologic study of pepsinogens in stomach cancer].
作者信息
Shimbireva I B, Frank G A, Pugachev K K, Avdeev G I
出版信息
Vopr Onkol. 1988;34(4):426-9.
PMID:3287763
Abstract
Pepsinogens were studied in histological specimens of gastric carcinoma by indirect immunoperoxidase method. They were identified in 14 out of 24 intestinal tumors and in 2 out of 6 mixed carcinomas, but none was found in any of 10 diffuse carcinomas. Pepsinogen C was found in all pepsinogen-positive tumors, pepsinogen A--in 11 of them, and an antigen common with swine pepsin--in 2 tumors only. The pepsinogens were also observed in metastases of pepsinogen-positive primary tumors.
摘要
采用间接免疫过氧化物酶法对胃癌组织学标本中的胃蛋白酶原进行了研究。在24例肠型肿瘤中有14例检测到胃蛋白酶原，6例混合型癌中有2例检测到胃蛋白酶原，但10例弥漫型癌中均未检测到。在所有胃蛋白酶原阳性肿瘤中均发现了胃蛋白酶原C，其中11例发现了胃蛋白酶原A，仅在2例肿瘤中发现了与猪胃蛋白酶共有的抗原。在胃蛋白酶原阳性原发性肿瘤的转移灶中也观察到了胃蛋白酶原。
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