Department of Molecular Biology, University of Gdańsk, Gdańsk, Poland.
FEBS Lett. 2020 Oct;594(20):3363-3370. doi: 10.1002/1873-3468.13908. Epub 2020 Sep 6.
We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that MPS cells might be less, rather than more, susceptible to SARS-CoV-2 infection.
我们使用转录组学（RNA-seq）分析来确定患有各种类型和亚型黏多糖贮积症（MPS）的患者是否更容易感染 2019 年冠状病毒病（COVID-19）。在 MPS 细胞系中估计了编码可能参与 SARS-CoV-2 发展的蛋白质的基因的表达水平。四个基因（GTF2F2、RAB18、TMEM97、PDE4DIP）编码可能促进病毒发展的蛋白质，而两个基因（FBN1、MFGE8）的产物可能干扰病毒的传播，在大多数 MPS 类型中上调。尽管呼吸道狭窄和 MPS 特有的浓稠粘液的产生是 COVID-19 的危险因素，但转录组学分析表明，MPS 细胞可能不太容易感染 SARS-CoV-2，而不是更易感染。
