Clinical Research Center, Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Eur J Pharmacol. 2020 Nov 15;887:173530. doi: 10.1016/j.ejphar.2020.173530. Epub 2020 Sep 1.
The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. The lack of vaccine and effective therapeutic agents for the disease prompted world-wide effort to test those antiviral therapeutics already in use for other diseases. Another interesting approach has been based on the pathological sequel of the disease that involve severe inflammatory reaction (or the cytokine storm) associated with pneumonia in critically ill patients. This article outlines the prophylaxis therapeutic potential of supplements vitamins and micronutrients in COVID-19. By ameliorating the inflammatory and oxidative stress associated with the disease and some direct antiviral effects, the application of these agents as adjuvants and other alternative approaches are discussed. Available clinical trials including those currently registered on these supplements are scrutinized.
新型冠状病毒（SARS-CoV-2）引发的 COVID-19 在过去几个月里对全球造成了影响，造成了前所未有的社会经济破坏，已有超过 60 万人死亡。由于缺乏针对该疾病的疫苗和有效治疗药物，全球各国都在努力测试那些已用于治疗其他疾病的抗病毒药物。另一种有趣的方法是基于疾病的病理后果，即与重症患者肺炎相关的严重炎症反应（或细胞因子风暴）。本文概述了维生素和微量营养素补充剂在 COVID-19 中的预防治疗潜力。通过改善与疾病相关的炎症和氧化应激以及一些直接的抗病毒作用，讨论了将这些药物作为佐剂和其他替代方法的应用。对现有的临床试验进行了审查，包括目前针对这些补充剂注册的临床试验。
