Hiffler Laurent, Rakotoambinina Benjamin
Independent researcher, Lagny-sur-Marne, France.
LRI Isotopic Medicine Lab, University of Antananarivo, Antananarivo, Madagascar.
Front Nutr. 2020 Sep 4;7:164. doi: 10.3389/fnut.2020.00164. eCollection 2020.
SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly. Selenium (Se), a natural trace element, has a key and complex role in the immune system. It is well-documented that Se deficiency is associated with higher susceptibility to RNA viral infections and more severe disease outcome. In this article, we firstly present evidence on how Se deficiency promotes mutations, replication and virulence of RNA viruses. Next, we review how Se might be beneficial via restoration of host antioxidant capacity, reduction of apoptosis and endothelial cell damages as well as platelet aggregation. It also appears that low Se status is a common finding in conditions considered at risk of severe COVID-19, especially in the elderly. Finally, we present a rationale for Se use at different stages of COVID-19. Se has been overlooked but may have a significant place in COVID-19 spectrum management, particularly in vulnerable elderly, and might represent a game changer in the global response to COVID-19.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种导致新冠疫情的RNA病毒，截至2020年5月23日，该疫情已在全球造成超过34万人死亡，其中大多数是老年人。硒（Se）作为一种天然微量元素，在免疫系统中发挥着关键而复杂的作用。有充分记录表明，硒缺乏与RNA病毒感染的易感性增加和更严重的疾病结局相关。在本文中，我们首先阐述硒缺乏如何促进RNA病毒的突变、复制和毒力的证据。接下来，我们综述硒如何通过恢复宿主抗氧化能力、减少细胞凋亡和内皮细胞损伤以及血小板聚集而发挥有益作用。此外，低硒状态在被认为有严重新冠风险的情况下很常见，尤其是在老年人中。最后，我们提出在新冠不同阶段使用硒的理论依据。硒一直被忽视，但在新冠疫情的管理中可能具有重要地位，特别是对易受影响的老年人，可能会成为全球应对新冠疫情的一个改变局面的因素。
