Human Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445, Strassen, Luxembourg.
Human Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445, Strassen, Luxembourg.
Environ Pollut. 2020 Dec;267:115425. doi: 10.1016/j.envpol.2020.115425. Epub 2020 Aug 15.
Humans are exposed to various anthropogenic chemicals in daily life, including endocrine-disrupting chemicals (EDCs). However, there are limited data on chronic, low-level exposure to such contaminants among the general population. Here hair analysis was used to investigate the occurrence of four polychlorinated biphenyls (PCBs), seven polybrominated diphenyl ethers (PBDEs) and two bisphenols (BPs) in 204 Chinese women living in the urban areas of Baoding and Dalian and 311 pregnant French women. All the PCBs and PBDEs tested here were more frequently detected in the hair samples of the French women than in those of the Chinese women. In both cohorts, PCB 180 and BDE 47 were the dominant PCB and PBDE congener, respectively. PCB 180 was found in 82% of the French women and 44% of the Chinese women, while the corresponding values of BDE 47 were 54% and 11%, respectively. A discriminant analysis further demonstrated the difference in PCBs and PBDEs exposure profile between the two cohorts. These results demonstrate that hair analysis is sufficiently sensitive to detect exposure to these pollutants and highlight differences in exposure between populations even at environmental levels. Although BPA and BPS were found in 100% of the hair samples in both cohorts, the French women had significantly higher levels of BPA and BPS than the Chinese women. The median concentrations of BPA were one order of magnitude higher than BPS in both the Chinese (34.9 versus 2.84 pg/mg) and the French women (118 versus 8.01 pg/mg) respectively. Our results suggest that both French and Chinese populations were extensively exposed to BPA and BPS.
人类在日常生活中会接触到各种人为化学物质，包括内分泌干扰化学物质（EDCs）。然而，关于普通人群中此类污染物的慢性、低水平暴露，数据有限。本研究采用毛发分析方法，检测了 204 名居住在保定和大连城区的中国妇女和 311 名法国孕妇毛发中 4 种多氯联苯（PCBs）、7 种多溴二苯醚（PBDEs）和 2 种双酚（BPs）的含量。在所检测的 PCBs 和 PBDEs 中，法国妇女毛发样本中的含量均高于中国妇女。在这两个队列中，PCB180 和 BDE47 分别是最主要的 PCBs 和 PBDE 同系物。82%的法国妇女和 44%的中国妇女体内检出 PCB180，相应的 BDE47 检出率为 54%和 11%。判别分析进一步证实了这两个队列中 PCBs 和 PBDEs 暴露谱的差异。这些结果表明，毛发分析能够充分敏感地检测到这些污染物的暴露情况，并突出了不同人群即使在环境水平下的暴露差异。尽管两个队列的毛发样本中均检出了 100%的 BPA 和 BPS，但法国妇女体内的 BPA 和 BPS 水平显著高于中国妇女。中国妇女和法国妇女体内 BPA 的中位数浓度分别比 BPS 高一个数量级（分别为 34.9 与 2.84 pg/mg 和 118 与 8.01 pg/mg）。我们的研究结果表明，中国和法国人群均广泛暴露于 BPA 和 BPS。
