Żaczek Maciej, Weber-Dąbrowska Beata, Górski Andrzej
Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Antibiotics (Basel). 2020 Sep 1;9(9):564. doi: 10.3390/antibiotics9090564.
Facing antibiotic resistance has provoked a continuously growing focus on phage therapy. Although the greatest emphasis has always been placed on phage treatment in humans, behind phage application lies a complex approach that can be usefully adopted by the food industry, from hatcheries and croplands to ready-to-eat products. Such diverse businesses require an efficient method for combating highly pathogenic bacteria since antibiotic resistance concerns every aspect of human life. Despite the vast abundance of phages on Earth, the aquatic environment has been considered their most natural habitat. Water favors multidirectional Brownian motion and increases the possibility of contact between phage particles and their bacterial hosts. As the global production of aquatic organisms has rapidly grown over the past decades, phage treatment of bacterial infections seems to be an obvious and promising solution in this market sector. Pathogenic bacteria, such as and , have already proved to be responsible for mass mortalities in aquatic systems, resulting in economic losses. The main objective of this work is to summarize, from a scientific and industry perspective, the recent data regarding phage application in the form of targeted probiotics and therapeutic agents in aquaculture niches.
面对抗生素耐药性问题，人们对噬菌体疗法的关注持续增加。尽管一直以来人们最关注的是噬菌体疗法在人类治疗中的应用，但噬菌体应用背后是一种复杂的方法，食品行业（从孵化场和农田到即食产品）可以有效地采用这种方法。由于抗生素耐药性涉及人类生活的方方面面，这些不同的行业需要一种有效的方法来对抗高致病性细菌。尽管地球上噬菌体数量众多，但水生环境一直被认为是它们最自然的栖息地。水有利于多向布朗运动，并增加了噬菌体颗粒与其细菌宿主之间接触的可能性。在过去几十年里，随着全球水生生物产量的迅速增长，噬菌体治疗细菌感染似乎是这个市场领域一个明显且有前景的解决方案。诸如[具体细菌名称1]和[具体细菌名称2]等致病细菌已被证明是造成水生系统大量死亡的原因，导致了经济损失。这项工作的主要目标是从科学和行业角度总结近期有关噬菌体作为靶向益生菌和治疗剂在水产养殖领域应用的数据。
