Sealy Naria, Hankinson Susan E, Houghton Serena C
Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA01003, USA.
Br J Nutr. 2021 May 28;125(10):1148-1156. doi: 10.1017/S0007114520003499. Epub 2020 Sep 4.
Olive oil consumption has been suggested to be inversely associated with breast cancer risk, probably due to its high MUFA and polyphenol content. The purpose of this meta-analysis was to assess the association between olive oil and breast cancer risk, including assessing the potential for a dose-response association. We performed a systematic search of PubMed, Web of Science, CINAHL and Cochrane Central Register of Controlled Trials through June 2020, identifying ten observational studies (two prospective studies and eight case-control studies) for meta-analysis. We estimated summary OR and 95 % CI for the highest v. lowest olive oil intake category across studies using random effect models and assessed the dose-response relationship between olive oil and breast cancer risk using restricted cubic splines. The summary OR comparing women with the highest intake to those with the lowest category of olive oil intake was 0·48 (95 % CI 0·09, 2·70) in prospective studies and 0·76 (95 % CI 0·54, 1·06) in case-control studies, with evidence of substantial study heterogeneity (prospective I2 = 89 %, case-control I2 = 82 %). There was no significant dose-response relationship for olive oil and breast cancer risk; the OR for a 14 g/d increment was 0·93 (95 % CI 0·83, 1·04). There may be a potential inverse association between olive oil intake and breast cancer; however, since the estimates are non-significant and the certainty level is very low, additional prospective studies with better assessment of olive oil intake are needed.
橄榄油的摄入量与乳腺癌风险呈负相关，这可能与其富含单不饱和脂肪酸（MUFA）和多酚有关。本荟萃分析旨在评估橄榄油与乳腺癌风险之间的关联，包括评估剂量反应关系的可能性。我们通过检索PubMed、Web of Science、CINAHL和Cochrane对照试验中心注册库，截至2020年6月进行了系统的文献检索，共纳入10项观察性研究（2项前瞻性研究和8项病例对照研究）进行荟萃分析。我们使用随机效应模型估计了各研究中橄榄油摄入量最高组与最低组的汇总比值比（OR）及95%置信区间（CI），并使用受限立方样条评估橄榄油与乳腺癌风险之间的剂量反应关系。在前瞻性研究中，橄榄油摄入量最高组与最低组女性的汇总OR为0.48（95%CI 0.09，2.70），病例对照研究中为0.76（95%CI 0.54，1.06），且存在显著的研究异质性（前瞻性研究I2 = 89%，病例对照研究I2 = 82%）。橄榄油与乳腺癌风险之间无显著的剂量反应关系；每日增加14克橄榄油摄入量的OR为0.93（95%CI 0.83，1.04）。橄榄油摄入量与乳腺癌之间可能存在潜在的负相关；然而，由于估计结果不显著且确定性水平非常低，因此需要开展更多前瞻性研究，以更好地评估橄榄油摄入量。
