Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong 524023, China.
College of Agriculture, South China Agricultural University, Guangzhou 510046, China.
Biomed Pharmacother. 2020 Sep;129:110494. doi: 10.1016/j.biopha.2020.110494. Epub 2020 Jul 10.
Bone cells in the human body are continuously engaged in cellular metabolism, including the interaction between bone cells, the interaction between the erythropoietic cells of the bone marrow and stromal cells, for the remodeling and reconstruction of bone. Osteoclasts and osteoblasts play an important role in bone metabolism. Diseases occur when bone metabolism is abnormal, but little is known about the signaling pathways that affect bone metabolism. The study of these signaling pathways will help us to use the relevant techniques to intervene, so as to improve the condition. The study of these signaling pathways will help us to use the relevant techniques to intervene, so as to improve the condition. I believe they will shine in the diagnosis and treatment of future clinical bone diseases.
人体内的骨细胞持续参与细胞代谢，包括骨细胞之间的相互作用、骨髓造血细胞与基质细胞之间的相互作用，以实现骨骼的重塑和重建。破骨细胞和成骨细胞在骨代谢中起着重要作用。当骨代谢异常时就会发生疾病，但人们对影响骨代谢的信号通路知之甚少。研究这些信号通路将有助于我们利用相关技术进行干预，从而改善病情。我相信它们将在未来临床骨病的诊断和治疗中大放异彩。
