骨碎补总黄酮对骨代谢生化指标的影响：一项系统评价与Meta分析
Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis.
作者信息
Li Wei, Zhang Zechen, Li Yuyi, Wu Zhenyu, Wang Chengjie, Huang Zhen, Ye Baisheng, Jiang Xin, Yang Xiaolong, Shi Xiaolin
机构信息
The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Front Pharmacol. 2024 Sep 10;15:1443235. doi: 10.3389/fphar.2024.1443235. eCollection 2024.
BACKGROUND
Evidence shows that the total flavonoids of Rhizoma Drynariae (TFRD) can improve bone mineral density (BMD). However, there is no evidence to summarize the improvement of biochemical indicators of bone metabolism (BIBM).
METHODS
The PubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, Chongqing VIP Information Database (VIP) and SinoMed were searched from inception to 6 May 2024. The final included studies performed meta-analyses using RevMan 5.3.
RESULTS
Nine randomized controlled trials (RCTs) were ultimately included. The TFRD group had higher bone gla protein (BGP) and type I procollagen-N-propeptide (PINP) compared to the Other therapies (WMD: 5.11; 95% CI: 3.37, 6.84; < 0.00001; WMD: 13.89; 95% CI: 11.81, 15.97; < 0.00001). The tartrate-resistant acid phosphatase (TRACP) decreased significantly (WMD: -1.34; 95% CI: -1.62, -1.06; < 0.00001). The alkaline phosphatase (ALP) increased significantly (WMD: 7.47; 95% CI: 6.29, 8.66; < 0.00001). There were no significant differences in serum calcium (SC) or serum phosphorus (SP) levels between the TFRD and control groups (WMD: 0.08; 95% CI: -0.04, 0.20; = 0.17; WMD: 0.02; 95% CI: -0.02, 0.05; = 0.36).
CONCLUSION
TFRD can stimulate bone formation and prevent bone resorption in osteoporosis (OP) patients, but it has no effect on SC and SP.
SYSTEMATIC REVIEW REGISTRATION
背景
有证据表明骨碎补总黄酮（TFRD）可提高骨密度（BMD）。然而，尚无证据总结其对骨代谢生化指标（BIBM）的改善情况。
方法
检索了从建库至2024年5月6日的PubMed、Web of Science、Cochrane图书馆、Embase、中国知网（CNKI）、万方数据库、维普资讯数据库（VIP）和中国生物医学文献数据库（SinoMed）。最终纳入的研究使用RevMan 5.3进行荟萃分析。
结果
最终纳入9项随机对照试验（RCT）。与其他治疗方法相比，TFRD组骨钙素（BGP）和I型前胶原氨基端前肽（PINP）水平更高（加权均数差：5.11；95%置信区间：3.37，6.84；P<0.00001；加权均数差：13.89；95%置信区间：11.81，15.97；P<0.00001）。抗酒石酸酸性磷酸酶（TRACP）显著降低（加权均数差：-1.34；95%置信区间：-1.62，-1.06；P<0.00001）。碱性磷酸酶（ALP）显著升高（加权均数差：7.47；95%置信区间：6.29，8.66；P<0.00001）。TFRD组与对照组之间血清钙（SC）或血清磷（SP）水平无显著差异（加权均数差：0.08；95%置信区间：-0.04，0.20；P = 0.17；加权均数差：0.02；95%置信区间：-0.02，0.05；P = 0.36）。
结论
TFRD可刺激骨质疏松症（OP）患者的骨形成并防止骨吸收，但对SC和SP无影响。
系统评价注册
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