• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

骨碎补总黄酮对骨代谢生化指标的影响：一项系统评价与Meta分析

Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis.

作者信息

Li Wei, Zhang Zechen, Li Yuyi, Wu Zhenyu, Wang Chengjie, Huang Zhen, Ye Baisheng, Jiang Xin, Yang Xiaolong, Shi Xiaolin

机构信息

The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Front Pharmacol. 2024 Sep 10;15:1443235. doi: 10.3389/fphar.2024.1443235. eCollection 2024.

DOI:10.3389/fphar.2024.1443235
PMID:39359242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11445651/
Abstract

BACKGROUND

Evidence shows that the total flavonoids of Rhizoma Drynariae (TFRD) can improve bone mineral density (BMD). However, there is no evidence to summarize the improvement of biochemical indicators of bone metabolism (BIBM).

METHODS

The PubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, Chongqing VIP Information Database (VIP) and SinoMed were searched from inception to 6 May 2024. The final included studies performed meta-analyses using RevMan 5.3.

RESULTS

Nine randomized controlled trials (RCTs) were ultimately included. The TFRD group had higher bone gla protein (BGP) and type I procollagen-N-propeptide (PINP) compared to the Other therapies (WMD: 5.11; 95% CI: 3.37, 6.84; < 0.00001; WMD: 13.89; 95% CI: 11.81, 15.97; < 0.00001). The tartrate-resistant acid phosphatase (TRACP) decreased significantly (WMD: -1.34; 95% CI: -1.62, -1.06; < 0.00001). The alkaline phosphatase (ALP) increased significantly (WMD: 7.47; 95% CI: 6.29, 8.66; < 0.00001). There were no significant differences in serum calcium (SC) or serum phosphorus (SP) levels between the TFRD and control groups (WMD: 0.08; 95% CI: -0.04, 0.20; = 0.17; WMD: 0.02; 95% CI: -0.02, 0.05; = 0.36).

CONCLUSION

TFRD can stimulate bone formation and prevent bone resorption in osteoporosis (OP) patients, but it has no effect on SC and SP.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/PROSPERO/.

摘要

背景

有证据表明骨碎补总黄酮（TFRD）可提高骨密度（BMD）。然而，尚无证据总结其对骨代谢生化指标（BIBM）的改善情况。

方法

检索了从建库至2024年5月6日的PubMed、Web of Science、Cochrane图书馆、Embase、中国知网（CNKI）、万方数据库、维普资讯数据库（VIP）和中国生物医学文献数据库（SinoMed）。最终纳入的研究使用RevMan 5.3进行荟萃分析。

结果

最终纳入9项随机对照试验（RCT）。与其他治疗方法相比，TFRD组骨钙素（BGP）和I型前胶原氨基端前肽（PINP）水平更高（加权均数差：5.11；95%置信区间：3.37，6.84；P<0.00001；加权均数差：13.89；95%置信区间：11.81，15.97；P<0.00001）。抗酒石酸酸性磷酸酶（TRACP）显著降低（加权均数差：-1.34；95%置信区间：-1.62，-1.06；P<0.00001）。碱性磷酸酶（ALP）显著升高（加权均数差：7.47；95%置信区间：6.29，8.66；P<0.00001）。TFRD组与对照组之间血清钙（SC）或血清磷（SP）水平无显著差异（加权均数差：0.08；95%置信区间：-0.04，0.20；P = 0.17；加权均数差：0.02；95%置信区间：-0.02，0.05；P = 0.36）。

结论

TFRD可刺激骨质疏松症（OP）患者的骨形成并防止骨吸收，但对SC和SP无影响。

系统评价注册

https://www.crd.york.ac.uk/PROSPERO/ 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/630ebdce9bc5/fphar-15-1443235-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/26236a390989/fphar-15-1443235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/7ea700bda819/fphar-15-1443235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/de8b78c12e7f/fphar-15-1443235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/fa0682d05e78/fphar-15-1443235-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/59388f3aa7d3/fphar-15-1443235-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/088971532309/fphar-15-1443235-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/db2fd9938806/fphar-15-1443235-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/630ebdce9bc5/fphar-15-1443235-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/26236a390989/fphar-15-1443235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/7ea700bda819/fphar-15-1443235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/de8b78c12e7f/fphar-15-1443235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/fa0682d05e78/fphar-15-1443235-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/59388f3aa7d3/fphar-15-1443235-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/088971532309/fphar-15-1443235-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/db2fd9938806/fphar-15-1443235-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f8a/11445651/630ebdce9bc5/fphar-15-1443235-g008.jpg

相似文献

1
Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis.骨碎补总黄酮对骨代谢生化指标的影响：一项系统评价与Meta分析
Front Pharmacol. 2024 Sep 10;15:1443235. doi: 10.3389/fphar.2024.1443235. eCollection 2024.
2
Total flavonoids of combined with calcium attenuate osteoporosis by reducing reactive oxygen species generation.联合钙的总黄酮通过减少活性氧的产生减轻骨质疏松症。
Exp Ther Med. 2021 Jun;21(6):618. doi: 10.3892/etm.2021.10050. Epub 2021 Apr 14.
3
The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats.盐酸二甲双胍联合淫羊藿总黄酮治疗去卵巢骨质疏松大鼠的作用机制。
Biomed Pharmacother. 2023 Sep;165:115181. doi: 10.1016/j.biopha.2023.115181. Epub 2023 Jul 18.
4
Chinese medicine Gushukang capsule for treating primary osteoporosis: a systematic review and meta-analysis.中药骨疏康胶囊治疗原发性骨质疏松症的系统评价和 Meta 分析。
J Orthop Surg Res. 2023 Nov 8;18(1):845. doi: 10.1186/s13018-023-04264-9.
5
Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice.骨碎补总黄酮治疗骨质疏松性骨折：临床应用意义
Drug Des Devel Ther. 2017 Jun 23;11:1881-1890. doi: 10.2147/DDDT.S139804. eCollection 2017.
6
Exercise vs Conventional Treatment for Treatment of Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.运动与常规治疗治疗原发性骨质疏松症的比较：随机对照试验的系统评价和荟萃分析。
Orthop Surg. 2021 Jul;13(5):1474-1487. doi: 10.1111/os.13036. Epub 2021 Jun 14.
7
Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens.从槲蕨根茎中提取的总黄酮膳食补充剂可改善笼养产蛋后期母鸡的骨骼健康。
Poult Sci. 2020 Oct;99(10):5047-5054. doi: 10.1016/j.psj.2020.06.057. Epub 2020 Jul 15.
8
The efficacy and safety of Gukang Capsule for primary osteoporosis: a systematic review and meta-analysis of randomized clinical trial.骨康胶囊治疗原发性骨质疏松症的疗效与安全性：一项随机临床试验的系统评价与Meta分析
Front Pharmacol. 2024 Jun 10;15:1394537. doi: 10.3389/fphar.2024.1394537. eCollection 2024.
9
Total flavonoids of Rhizoma Drynariae enhances CD31Emcn vessel formation and subsequent bone regeneration in rat models of distraction osteogenesis by activating PDGF‑BB/VEGF/RUNX2/OSX signaling axis.骨碎补总黄酮通过激活 PDGF-BB/VEGF/RUNX2/OSX 信号轴增强 CD31Emcn 血管形成和随后的牵引成骨大鼠模型中的骨再生。
Int J Mol Med. 2022 Sep;50(3). doi: 10.3892/ijmm.2022.5167. Epub 2022 Jul 7.
10
Active components and mechanisms of total flavonoids from Rhizoma Drynariae in enhancing cranial bone regeneration: An investigation employing serum pharmacochemistry and network pharmacology approaches.从密花角蕨总黄酮促进颅盖骨再生的活性成分及作用机制研究：基于血清药物化学和网络药理学方法。
J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117253. doi: 10.1016/j.jep.2023.117253. Epub 2023 Sep 29.

引用本文的文献

1
Correlation between postoperative serum bone metabolism levels and fracture healing in elderly osteoporotic fracture patients.老年骨质疏松性骨折患者术后血清骨代谢水平与骨折愈合的相关性
Endocrine. 2025 Jul 18. doi: 10.1007/s12020-025-04346-0.

本文引用的文献

1
The prevalence of osteoporotic fractures in the elderly in China: a systematic review and meta-analysis.中国老年人骨质疏松性骨折的患病率：系统评价和荟萃分析。
J Orthop Surg Res. 2023 Jul 27;18(1):536. doi: 10.1186/s13018-023-04030-x.
2
The prevalence of osteoporosis in China, a community based cohort study of osteoporosis.中国骨质疏松症的流行情况，一项基于社区的骨质疏松症队列研究。
Front Public Health. 2023 Feb 16;11:1084005. doi: 10.3389/fpubh.2023.1084005. eCollection 2023.
3
A low serum alkaline phosphatase may signal hypophosphatasia in osteoporosis clinic patients.
血清碱性磷酸酶水平低可能提示骨质疏松门诊患者存在低磷酸酯酶症。
Osteoporos Int. 2023 Feb;34(2):327-337. doi: 10.1007/s00198-022-06597-3. Epub 2022 Nov 24.
4
Jintiange combined with alfacalcidol improves muscle strength and balance in primary osteoporosis: A randomized, double-blind, double-dummy, positive-controlled, multicenter clinical trial.金天格联合阿法骨化醇改善原发性骨质疏松症患者的肌肉力量和平衡：一项随机、双盲、双模拟、阳性对照、多中心临床试验。
J Orthop Translat. 2022 Aug 24;35:53-61. doi: 10.1016/j.jot.2022.05.002. eCollection 2022 Jul.
5
Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes.密花豆总黄酮对去卵巢骨质疏松大鼠及成骨细胞的影响
Biomed Pharmacother. 2022 Sep;153:113379. doi: 10.1016/j.biopha.2022.113379. Epub 2022 Jul 12.
6
Total flavonoids of Rhizoma drynariae promote angiogenesis and osteogenesis in bone defects.骨碎补总黄酮促进骨缺损部位血管生成和骨生成。
Phytother Res. 2022 Sep;36(9):3584-3600. doi: 10.1002/ptr.7525. Epub 2022 Aug 12.
7
Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats.淫羊藿总黄酮对去卵巢大鼠骨髓脂肪组织的影响。
Front Endocrinol (Lausanne). 2022 Jun 6;13:900816. doi: 10.3389/fendo.2022.900816. eCollection 2022.
8
Naringin Alleviates HO-Inhibited Osteogenic Differentiation of Human Adipose-Derived Stromal Cells via Wnt/-Catenin Signaling.柚皮苷通过Wnt/β-连环蛋白信号通路减轻血红素加氧酶对人脂肪来源间充质干细胞成骨分化的抑制作用。
Evid Based Complement Alternat Med. 2022 Apr 29;2022:3126094. doi: 10.1155/2022/3126094. eCollection 2022.
9
UK clinical guideline for the prevention and treatment of osteoporosis.英国临床骨质疏松症预防和治疗指南。
Arch Osteoporos. 2022 Apr 5;17(1):58. doi: 10.1007/s11657-022-01061-5.
10
Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/β-catenin pathway.莪术总黄酮联合碳酸钙通过调控 Wnt3a/β-连环蛋白通路改善大鼠实验性骨质疏松症所致骨丢失。
J Orthop Surg Res. 2021 Dec 4;16(1):702. doi: 10.1186/s13018-021-02842-3.