Pethő Zoltán, Najder Karolina, Carvalho Tiago, McMorrow Roisin, Todesca Luca Matteo, Rugi Micol, Bulk Etmar, Chan Alan, Löwik Clemens W G M, Reshkin Stephan J, Schwab Albrecht
Institute of Physiology II, University Münster, 48147 Münster, Germany.
Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, 90126 Bari, Italy.
Cancers (Basel). 2020 Sep 2;12(9):2484. doi: 10.3390/cancers12092484.
Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors and transducers of altered pH. Cell adhesion molecules and cation channels are prominent membrane proteins, the majority of which is regulated by protons. The pathophysiological consequences of proton-sensitive ion channel function in cancer, however, are scarcely considered in the literature. Thus, the main focus of this review is to highlight possible events in tumor progression and tumor immunity where the pH sensitivity of cation channels could be of great importance.
特别是，间质酸中毒促进肿瘤细胞侵袭，并且是肿瘤免疫和肿瘤基质细胞失调的主要促成因素。细胞膜和整合膜蛋白通常作为pH改变的重要传感器和转换器。细胞粘附分子和阳离子通道是突出的膜蛋白，其中大多数受质子调节。然而，文献中几乎没有考虑质子敏感离子通道功能在癌症中的病理生理后果。因此，本综述的主要重点是强调阳离子通道的pH敏感性可能非常重要的肿瘤进展和肿瘤免疫中的可能事件。
