Professional Scientific Services, Eurofins Lancaster Laboratories, Lancaster, PA, 17605, USA.
Protein Engineering, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA, 92121, USA.
Peptides. 2020 Dec;134:170402. doi: 10.1016/j.peptides.2020.170402. Epub 2020 Sep 1.
Viral infectious diseases have resulted in millions of deaths throughout history and have created a significant public healthcare burden. Tremendous efforts have been placed by the scientific communities, health officials and government organizations to detect, treat, and prevent viral infection. However, the complicated life cycle and rapid genetic mutations of viruses demand continuous development of novel medicines with high efficacy and safety profiles. Peptides provide a promising outlook as a tool to combat the spread and re-emergence of viral infection. This article provides an overview of five viral infectious diseases with high global prevalence: influenza, chronic hepatitis B, acquired immunodeficiency syndrome, severe acute respiratory syndrome, and coronavirus disease 2019. The current and potential peptide-based therapies, vaccines, and diagnostics for each disease are discussed.
病毒性传染病在历史上导致了数百万人死亡，并给公共卫生保健带来了巨大负担。科学界、卫生官员和政府组织都做出了巨大努力来检测、治疗和预防病毒感染。然而，病毒复杂的生命周期和快速的遗传突变要求不断开发具有高效和安全特性的新型药物。肽类提供了一种有前途的工具，可用于对抗病毒感染的传播和再次出现。本文概述了五种具有高全球流行率的病毒性传染病：流感、慢性乙型肝炎、获得性免疫缺陷综合征、严重急性呼吸综合征和 2019 年冠状病毒病。讨论了针对每种疾病的当前和潜在的基于肽的疗法、疫苗和诊断方法。
