从 Raphia vinifera 中提取的甾体皂苷及其细胞毒性活性。
Steroidal saponins from Raphia vinifera and their cytotoxic activity.
机构信息
Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
出版信息
Steroids. 2020 Nov;163:108724. doi: 10.1016/j.steroids.2020.108724. Epub 2020 Sep 1.
Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC values of 3.55 µM and 7.14 µM, respectively.
对 Raphia vinifera 的果实进行的植物化学分析导致分离出四种新的甾体皂苷（1-4），以及六种已知的次生代谢产物（6-10）。根据 NMR 和质谱数据分析以及化学降解反应，确定了分离化合物的结构。在所测试的化合物中，1 和 4 对敏感的 CCRF-CEM 白血病细胞系表现出最有前途的细胞毒性活性，IC 值分别为 3.55 µM 和 7.14 µM。
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