大理重楼根茎中的甾体皂苷

Steroidal saponins from the rhizomes of Paris delavayi.

作者信息

Zhang Ting, Liu Hai, Liu Xue-Ting, Chen Xiao-Qing, Wang Qiang

机构信息

Murad Research Center for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

出版信息

Steroids. 2009 Oct;74(10-11):809-13. doi: 10.1016/j.steroids.2009.04.012. Epub 2009 May 15.

DOI:10.1016/j.steroids.2009.04.012

PMID:19447124

Abstract

Two new steroidal saponins, padelaosides A (1) and B (2), along with two other known steroidal saponins (3 and 4) were isolated from the rhizomes of Paris delavayi. Their structures were elucidated by 1D and 2D NMR techniques, HRFTMS, physical data and chemical methods. The two different absolute configurations of fucose, assigned as l and d that were found on compounds 1 and 2, respectively, were simultaneously reported in a natural medicine for the first time.

摘要

从大理重楼根茎中分离得到两种新的甾体皂苷，即大理重楼皂苷A（1）和B（2），以及另外两种已知的甾体皂苷（3和4）。通过一维和二维核磁共振技术、高分辨飞行时间质谱、物理数据和化学方法对它们的结构进行了鉴定。首次在一种天然药物中同时报道了化合物1和2上分别确定的岩藻糖的两种不同绝对构型，分别指定为l型和d型。