Morris B, Courtice F C
Lymphology. 1977 Jun;10(2):62-70.
Studies of the free-floating lymphocytes and of the immunoglobulins in lymph collected over long periods of time from ducts draining individual tissues of the body as well as from the thoracic duct of the fetus in utero have been reviewed. The findings show that stimuli within the internal milieu act on different classes of lymphocytes to alter their migration pattern, morphology, metabolic activity, and range of immunological potentialities. As the lymphoid cells migrate between the blood, tissue fluid, and lymph, a continual process of reassortment occurs leading to the establishment of heterogeneous lymphoid cell populations in different regions of the lymphatic apparatus. It seems that the biological activities of these cells are not decided only in terms of a thymus or a bone-marrow origin. The immunoglobulins, like other proteins in lymph, are mainly derived by filtration from the circulating plasma. Some of the immunoglobulins and specific antibodies are synthesized, however, by lymphoid cells and secreted directly into the lymph.
对从引流身体各个组织的导管以及子宫内胎儿的胸导管中长时间收集的淋巴液中的游离淋巴细胞和免疫球蛋白进行的研究已被综述。研究结果表明，内环境中的刺激作用于不同类型的淋巴细胞，以改变它们的迁移模式、形态、代谢活性和免疫潜能范围。当淋巴细胞在血液、组织液和淋巴之间迁移时，会发生持续的重新组合过程，导致在淋巴器官的不同区域建立异质性淋巴细胞群体。这些细胞的生物学活性似乎并非仅由胸腺或骨髓来源决定。免疫球蛋白与淋巴中的其他蛋白质一样，主要通过从循环血浆中滤过而来。然而，一些免疫球蛋白和特异性抗体是由淋巴细胞合成并直接分泌到淋巴中的。
