Spry C J, Pflug A J, Janossy G, Humphrey J H
Clin Exp Immunol. 1980 Mar;39(3):750-5.
Studies were done to see whether large mononuclear cells in human afferent lymph possess cytoplasmic veils or Ia-like antigens on their surface. Small numbers of veiled cells were seen in lymph from five subjects: one with post-phlebitis oedema, one with trophic ulcers of the legs, one with common variable immoglobulin deficiency, and two control subjects. They were not seen in afferent lymph from two other patients with oedema of the legs, and one control subject. Only occasional large mononuclear (veiled) cells formed rosettes with IgG-coated erythrocytes, and they did not attach to glass after overnight culture. They had a distinctive nuclear structure and fluorescent antisera showed that their membranes and veils possessed large amounts of 'Ia-like' antigens. They did not have surface immunoglobulin or a monocyte membrane antigen. It was concluded that the membrane and nuclear structure of human large mononuclear (veiled) cells is in keeping with the possibility that they are derived from Langerhans' cells in the skin, and that they can become interdigitating cells in lymphoid tissues. It is suggested that these cells have an important role in the transport of antigens from the skin and the stimulation of T lymphocytes in lymphoid tissues.
开展了多项研究，以观察人体传入淋巴中的大单核细胞表面是否存在细胞质面纱或Ia样抗原。在五名受试者的淋巴中发现了少量带面纱细胞：一名患有静脉炎后水肿，一名患有腿部营养性溃疡，一名患有常见变异型免疫球蛋白缺乏症，以及两名对照受试者。在另外两名腿部水肿患者和一名对照受试者的传入淋巴中未发现此类细胞。只有偶尔的大单核（带面纱）细胞与IgG包被的红细胞形成花环，并且在过夜培养后它们不附着于玻璃。它们具有独特的核结构，荧光抗血清显示其细胞膜和面纱含有大量“Ia样”抗原。它们没有表面免疫球蛋白或单核细胞膜抗原。得出的结论是，人类大单核（带面纱）细胞的膜和核结构符合它们可能源自皮肤中的朗格汉斯细胞，并且它们可在淋巴组织中变成交错突细胞的可能性。有人提出，这些细胞在抗原从皮肤的转运以及淋巴组织中T淋巴细胞的刺激方面发挥重要作用。
