心力衰竭中兰尼碱受体2功能障碍的机制。 - Suppr

Mechanisms of ryanodine receptor 2 dysfunction in heart failure.

作者信息

Alvarado Francisco J, Valdivia Héctor H

机构信息

Department of Medicine, Division of Cardiovascular Medicine, and Cardiovascular Research Center, University of Wisconsin-Madison, Madison, WI, USA.

出版信息

Nat Rev Cardiol. 2020 Nov;17(11):748. doi: 10.1038/s41569-020-00443-x.

DOI:10.1038/s41569-020-00443-x

PMID:32901150

Abstract

摘要

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Mechanisms of ryanodine receptor 2 dysfunction in heart failure.心力衰竭中兰尼碱受体2功能障碍的机制。

Nat Rev Cardiol. 2020 Nov;17(11):748. doi: 10.1038/s41569-020-00443-x.

Reply to 'Mechanisms of ryanodine receptor 2 dysfunction in heart failure'.对“心力衰竭中兰尼碱受体2功能障碍的机制”的回复

Nat Rev Cardiol. 2020 Nov;17(11):749-750. doi: 10.1038/s41569-020-00444-w.

Stabilizing ryanodine receptor gating quiets arrhythmogenic events in human heart failure and atrial fibrillation.稳定兰尼碱受体门控可减少人类心力衰竭和心房颤动中的致心律失常事件。

Heart Rhythm. 2017 Mar;14(3):420-421. doi: 10.1016/j.hrthm.2016.10.005. Epub 2016 Oct 7.

The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.兰尼碱受体通道作为心房颤动的分子模式：病理生理和治疗意义。

Cardiovasc Res. 2011 Mar 1;89(4):734-43. doi: 10.1093/cvr/cvq324. Epub 2010 Oct 12.

Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca(2+)-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban: an insight into the mechanism of atrial electrical remodeling.人类心房颤动中L型钙通道和肌浆网Ca(2+)-ATP酶mRNA下调，而雷诺丁受体、肌集钙蛋白和受磷蛋白的mRNA无显著变化：对心房电重构机制的深入了解

J Am Coll Cardiol. 1999 Apr;33(5):1231-7. doi: 10.1016/s0735-1097(99)00008-x.

Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.兰尼碱受体2磷酸化在心力衰竭和心律失常中的作用：心脏病中围绕兰尼碱受体磷酸化的争议

Circ Res. 2014 Apr 11;114(8):1311-9; discussion 1319. doi: 10.1161/CIRCRESAHA.114.300568.

Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.兰尼碱受体介导的钙漏驱动转基因小鼠模型中心房颤动基质的进行性发展。

Circulation. 2014 Mar 25;129(12):1276-1285. doi: 10.1161/CIRCULATIONAHA.113.006611. Epub 2014 Jan 7.

Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure.靶向兰尼碱受体病理性释放：临床前进展及其对心律失常和心力衰竭治疗的潜在影响。

Expert Opin Ther Targets. 2020 Jan;24(1):25-36. doi: 10.1080/14728222.2020.1708326. Epub 2020 Jan 3.

The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis.心肌兰尼碱受体（钙释放通道）：在心力衰竭和心律失常发病机制中的新作用。

Cardiovasc Res. 2002 Dec;56(3):359-72. doi: 10.1016/s0008-6363(02)00574-6.

Calcium-mediated cellular triggered activity in atrial fibrillation.钙介导的心房颤动细胞触发活动。

J Physiol. 2017 Jun 15;595(12):4001-4008. doi: 10.1113/JP273048. Epub 2017 Mar 22.

引用本文的文献

Preventing the phosphorylation of RyR2 at canonical sites reduces Ca leak and promotes arrhythmia by reactivating the I current.阻止兰尼碱受体2（RyR2）在典型位点的磷酸化可减少钙泄漏，并通过重新激活I电流促进心律失常。

Nat Cardiovasc Res. 2025 Aug;4(8):976-990. doi: 10.1038/s44161-025-00693-3. Epub 2025 Aug 12.

Proton pump inhibitors and cardiovascular risk: a critical review.质子泵抑制剂与心血管风险：一项批判性综述。

Future Cardiol. 2024;20(14):779-794. doi: 10.1080/14796678.2024.2412910. Epub 2024 Oct 28.

Sex-dependent remodeling of right ventricular function in a rat model of pulmonary arterial hypertension.肺动脉高压大鼠模型右心室功能的性别依赖性重构。

Am J Physiol Heart Circ Physiol. 2024 Aug 1;327(2):H351-H363. doi: 10.1152/ajpheart.00098.2024. Epub 2024 Jun 7.

Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts.ryanodine 受体 2 抑制可减少心脏复极的离散度，改善收缩功能，并预防衰竭心脏中的心律失常性猝死。

Elife. 2023 Dec 11;12:RP88638. doi: 10.7554/eLife.88638.

Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells improve recovery from myocardial infarction in mice.人诱导多能干细胞来源的内皮细胞分泌的外泌体可改善小鼠心肌梗死后的恢复。

Stem Cell Res Ther. 2023 Sep 29;14(1):278. doi: 10.1186/s13287-023-03462-w.

RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease.丹曲林钠抑制 RyR2 具有抗心律失常作用，可防止慢性缺血性心脏病进一步的病理性重构，并改善心功能。

J Mol Cell Cardiol. 2023 Aug;181:67-78. doi: 10.1016/j.yjmcc.2023.05.009. Epub 2023 Jun 5.

Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension.兰尼碱受体 2 和 FK506 结合蛋白 12.6 解离在肺动脉高压中的作用。

J Gen Physiol. 2023 Mar 6;155(3). doi: 10.1085/jgp.202213100. Epub 2023 Jan 10.

Changes in cellular Ca and Na regulation during the progression towards heart failure.细胞内钙和钠调节在心力衰竭进展过程中的变化。

J Physiol. 2023 Mar;601(5):905-921. doi: 10.1113/JP283082. Epub 2022 Aug 22.

Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression.在兔模型中，兰尼碱受体 2 表达减少时，心脏功能和肾上腺素能反应得到保存。

J Mol Cell Cardiol. 2022 Jun;167:118-128. doi: 10.1016/j.yjmcc.2022.04.004. Epub 2022 Apr 9.

Luminal Oxidative Regulation of the Ryanodine Receptor: More Sides to the Story?兰尼碱受体的管腔氧化调节：故事还有更多面？

Circ Res. 2022 Mar 4;130(5):725-727. doi: 10.1161/CIRCRESAHA.122.320798. Epub 2022 Mar 3.

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Reply to 'Mechanisms of ryanodine receptor 2 dysfunction in heart failure'.对“心力衰竭中兰尼碱受体2功能障碍的机制”的回复

Nat Rev Cardiol. 2020 Nov;17(11):749-750. doi: 10.1038/s41569-020-00444-w.

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Mechanisms of ryanodine receptor 2 dysfunction in heart failure.

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