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噬菌体展示肽在肿瘤成像诊断与靶向治疗中的应用

Application of Phage-Displayed Peptides in Tumor Imaging Diagnosis and Targeting Therapy.

作者信息

Li Chunyan, Li Jia, Xu Ying, Zhan Ying, Li Yu, Song Tingting, Zheng Jiao, Yang Hong

机构信息

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Air Force Medical University, 127 West ChangLe Road, Xi'an, 710032 Shaanxi China.

518 Hospital of PLA, Xi'an, 710043 Shaanxi China.

出版信息

Int J Pept Res Ther. 2021;27(1):587-595. doi: 10.1007/s10989-020-10108-5. Epub 2020 Sep 3.

DOI:10.1007/s10989-020-10108-5
PMID:32901205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7471523/
Abstract

Phage display is an effective and powerful technique that provides a route to discovery unique peptides targeting to tumor cells. Specifically binding peptides are considered as the valuable target directing molecule fragments with potential efficiency to improve the current tumor clinic, and offer new approaches for tumor prevention, diagnosis and treatment. We focus on the recent advances in the isolation of tumor-targeting peptides by biopanning methods, with particular emphasis on molecular imaging, and pharmaceutical targeting therapy.

摘要

噬菌体展示是一种有效且强大的技术,它为发现靶向肿瘤细胞的独特肽提供了一条途径。特异性结合肽被认为是有价值的靶向分子片段,具有潜在的效能来改善当前的肿瘤临床治疗,并为肿瘤的预防、诊断和治疗提供新方法。我们重点关注通过淘选方法分离肿瘤靶向肽的最新进展,尤其侧重于分子成像和药物靶向治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0e/7471523/1c01eb04fdc4/10989_2020_10108_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0e/7471523/347dceee8aa5/10989_2020_10108_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0e/7471523/1c01eb04fdc4/10989_2020_10108_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0e/7471523/347dceee8aa5/10989_2020_10108_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac0e/7471523/1c01eb04fdc4/10989_2020_10108_Fig2_HTML.jpg

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本文引用的文献

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The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy.EPR 效应及超越:提高肿瘤靶向性和癌症纳米医学治疗效果的策略。
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In vivo tumor active cancer targeting and CT-fluorescence dual-modal imaging with nanoprobe based on gold nanorods and InP/ZnS quantum dots.基于金纳米棒和InP/ZnS量子点的纳米探针在体内肿瘤的主动靶向及CT-荧光双模态成像
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Int J Mol Sci. 2024 Jun 5;25(11):6219. doi: 10.3390/ijms25116219.
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Phage Display as a Medium for Target Therapy Based Drug Discovery, Review and Update.基于噬菌体展示的靶向治疗药物发现:综述与更新
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Generation of a helper phage for the fluorescent detection of peptide-target interactions by dual-display phages.通过双展示噬菌体生成辅助噬菌体用于荧光检测肽-靶相互作用。
Sci Rep. 2023 Nov 2;13(1):18927. doi: 10.1038/s41598-023-45087-2.
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