School of Molecular Sciences, University of Western Australia, Perth, WA, Australia.
inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States.
Front Immunol. 2020 Jul 21;11:1427. doi: 10.3389/fimmu.2020.01427. eCollection 2020.
Short chain fatty acids (SFCAs) are microbial metabolites produced in the gut upon fermentation of dietary fiber. These metabolites interact with the host immune system and can elicit epigenetic effects. There is evidence to suggest that SCFAs may play a role in the developmental programming of immune disorders and obesity, though evidence in humans remains sparse. Here we have quantified human milk (HM) SCFA levels in an international cohort of atopic and non-atopic mothers ( = 109). Our results demonstrate that human milk contains detectable levels of the SCFAs acetate, butyrate, and formate. Samples from atopic mothers had significantly lower concentrations of acetate and butyrate than those of non-atopic mothers. HM SCFA levels in atopic and non-atopic women also varied based on maternal country of residence (Australia, Japan, Norway, South Africa, USA). Reduced exposure to HM SCFA in early life may program atopy or overweight risk in breastfed infants.
短链脂肪酸（SCFAs）是膳食纤维在肠道发酵时产生的微生物代谢产物。这些代谢产物与宿主免疫系统相互作用，并能引发表观遗传效应。有证据表明，SCFAs 可能在免疫紊乱和肥胖的发育编程中发挥作用，但人类的证据仍然很少。在这里，我们在一个过敏和非过敏母亲的国际队列（= 109）中定量了人乳（HM）中的 SCFA 水平。我们的结果表明，人乳中含有可检测水平的 SCFAs，即乙酸盐、丁酸盐和甲酸盐。与非过敏母亲相比，过敏母亲的样本中乙酸盐和丁酸盐的浓度明显更低。过敏和非过敏妇女的 HM SCFA 水平也因母亲居住的国家（澳大利亚、日本、挪威、南非、美国）而异。生命早期接触 HM SCFA 的减少可能会使母乳喂养的婴儿面临特应性或超重的风险。
