Balcázar Micaela, Cañizares Stalin, Borja Tatiana, Pontón Patricia, Bisiou Sirivanh, Carabasse Eva, Bacilieri Angela, Canavese Celia, Diaz Ramiro F, Cabrera Francisco, Caicedo Andrés
Escuela de Medicina, Colegio de Ciencias de la Salud COCSA, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Servicio de Patología, Hospital Voz Andes, Quito, Ecuador.
Front Bioeng Biotechnol. 2020 Aug 13;8:919. doi: 10.3389/fbioe.2020.00919. eCollection 2020.
The perception of mitochondria as only the powerhouse of the cell has dramatically changed in the last decade. It is now accepted that in addition to being essential intracellularly, mitochondria can promote cellular repair when transferred from healthy to damaged cells. The artificial mitochondria transfer/transplant (AMT/T) group of techniques emulate this naturally occurring process and have been used to develop therapies to treat a range of diseases including cardiac and neurodegenerative. Mitochondria accumulate damage with time, resulting in cellular senescence. Skin cells and its mitochondria are profoundly affected by ultraviolet radiation and other factors that induce premature and accelerated aging. In this article, we propose the basis to use AMT/T to treat skin aging by transferring healthy mitochondria to senescent cells, possibly revitalizing them. We provide insightful information about how skin structure, components, and cells could age rapidly depending on the amount of damage received. Arguments are shown in favor of the use of AMT/T to treat aging skin and its cells, among them the possibility to stop free radical production, add new genetic material, and provide an energetic boost to help cells prolong their viability over time. This article intends to present one of the many aspects in which mitochondria could be used as a universal treatment for cell and tissue damage and aging.
在过去十年中，线粒体仅被视为细胞动力源的观念已发生了巨大变化。现在人们认识到，线粒体除了在细胞内必不可少外，当从健康细胞转移到受损细胞时，还能促进细胞修复。人工线粒体转移/移植（AMT/T）技术组模拟了这一自然发生的过程，并已被用于开发治疗包括心脏和神经退行性疾病在内的一系列疾病的疗法。线粒体随着时间的推移会积累损伤，导致细胞衰老。皮肤细胞及其线粒体受到紫外线辐射和其他导致过早和加速衰老的因素的深刻影响。在本文中，我们提出了通过将健康的线粒体转移到衰老细胞中来治疗皮肤衰老的依据，这可能会使它们恢复活力。我们提供了有深刻见解的信息，说明皮肤结构、成分和细胞如何会根据所受损伤的程度而迅速衰老。文中展示了支持使用AMT/T治疗衰老皮肤及其细胞的论据，其中包括停止自由基产生、添加新的遗传物质以及提供能量提升以帮助细胞随着时间延长其活力的可能性。本文旨在阐述线粒体可作为细胞和组织损伤及衰老的通用治疗方法的众多方面之一。
