Reshi Mohd Salim, Yadav Deepa, Uthra Chhavi, Shrivastava Sadhana, Shukla Sangeeta
Toxicology and Pharmacology Lab., Department of Zoology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, Jammu and Kashmir 185234, India.
UNESCO- Trace Element Satellite Center School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh 474011, India.
Toxicol Res (Camb). 2020 Jun 17;9(4):406-412. doi: 10.1093/toxres/tfaa040. eCollection 2020 Jul.
Present study was planned to investigate the ameliorative effect of silver nanoparticles (AgNPs) on acetaminophen-induced nephrotoxicity. Our results demonstrate that therapy of AgNPs at three different doses (50, 100 and 150 μg/kg once only) prevented the acetaminophen (2 g/kg once only) induced acute renal toxicity. AgNPs treated animals also show less intensity in the histological alterations in kidneys and corroborating the results of analysis of serum urea and creatinine. In addition, AgNPs therapy prevented the acetaminophen-induced oxidative stress, which was confirmed by the alleviated lipid peroxidation, enhanced renal reduced glutathione content and restored enzymatic activities of superoxide dismutase, catalase and adenosine triphosphatase in kidney. Thus, our results demonstrate a possible protective potential of AgNPs on renal toxicity induced by acetaminophen. This study will definitely lead to the development of therapeutic drug against nephrotoxicity, after further clinical and preclinical studies.
本研究旨在探讨银纳米颗粒（AgNPs）对乙酰氨基酚诱导的肾毒性的改善作用。我们的结果表明，三种不同剂量（仅单次50、100和150μg/kg）的AgNPs治疗可预防乙酰氨基酚（仅单次2g/kg）诱导的急性肾毒性。接受AgNPs治疗的动物肾脏组织学改变的程度也较轻，血清尿素和肌酐分析结果也证实了这一点。此外，AgNPs治疗可预防乙酰氨基酚诱导的氧化应激，这通过减轻脂质过氧化、提高肾脏中还原型谷胱甘肽含量以及恢复肾脏中超氧化物歧化酶、过氧化氢酶和三磷酸腺苷酶的酶活性得到证实。因此，我们的结果表明AgNPs对乙酰氨基酚诱导的肾毒性具有潜在的保护作用。经过进一步的临床和临床前研究，本研究肯定会推动针对肾毒性的治疗药物的开发。
