Zeng Zhou, Roussakis Andreas-Antonios, Lao-Kaim Nicholas P, Piccini Paola
Department of Brain Sciences, Imperial College London, Neurology Imaging Unit, London, UK; Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Department of Brain Sciences, Imperial College London, Neurology Imaging Unit, London, UK.
Neurobiol Aging. 2020 Nov;95:264-270. doi: 10.1016/j.neurobiolaging.2020.07.012. Epub 2020 Jul 21.
Parkinson's disease (PD) is increasingly thought to be associated with glial pathology. Recently, research in neurodegenerative disorders has applied a greater focus to better understanding the role of astrocytes in the disease pathophysiology. In this article, we review results from the latest preclinical and clinical work, including functional imaging studies on astrocytes in PD and highlight key molecules that may prove valuable as biomarkers. We discuss how astrocytes may contribute to the initiation and progression of PD. We additionally present trials of investigational medicinal products and the current background for the design of future clinical trials.
帕金森病（PD）越来越被认为与神经胶质病理有关。最近，神经退行性疾病的研究更加注重更好地理解星形胶质细胞在疾病病理生理学中的作用。在本文中，我们回顾了最新的临床前和临床研究结果，包括对帕金森病中星形胶质细胞的功能成像研究，并强调了可能作为生物标志物具有重要价值的关键分子。我们讨论了星形胶质细胞如何促进帕金森病的发生和发展。此外，我们还介绍了研究用药品的试验以及未来临床试验设计的当前背景。
