Tribet Christophe, Vial Florent
Physico-chimie des Polymères et Milieux Dispersés, CNRS UMR 7615 and Université Paris 6, ESPCI, 10 rue Vauquelin, F-75005 Paris, France.
Soft Matter. 2007 Dec 11;4(1):68-81. doi: 10.1039/b708431p.
This review summarizes recent investigations on the association of macromolecules on lipid bilayers. Hydrophilic and flexible polymers can form soft coronae tenuously adsorbed or anchored on the lipid membrane. Other synthetic macromolecules are embedded in the apolar region of the membrane. Recent experimental and theoretical works focus on the perturbation of lipid properties achieved depending on the nature and strength of binding. Of importance to biomimicry, to tethered model membranes, and drug carriers, the effects achievable include modulation of the lateral diffusivity of lipids, shape distortions, lateral segregations, formation of well-defined nanopores and ultimately the stimuli responsive disruption of the membrane.
本综述总结了近期关于脂质双层上大分子缔合的研究。亲水性柔性聚合物可形成松散吸附或锚定在脂质膜上的软冠层。其他合成大分子则嵌入膜的非极性区域。近期的实验和理论研究聚焦于根据结合的性质和强度对脂质性质产生的扰动。对于仿生学、拴系模型膜和药物载体而言重要的是，可实现的效应包括脂质横向扩散率的调节、形状畸变、横向 segregation（此处原文可能有误，推测可能是“segregation”，意为分离）、明确纳米孔的形成以及最终对膜的刺激响应性破坏。
