Koemel Nicholas A, Sciarrillo Christina M, Bode Katherine B, Dixon Madison D, Lucas Edralin A, Jenkins Nathaniel D M, Emerson Sam R
Oklahoma State University.
Int J Sport Nutr Exerc Metab. 2020 Sep 9;30(6):412-419. doi: 10.1123/ijsnem.2020-0063. Print 2020 Nov 1.
The consumption of a high-fat meal can induce postprandial lipemia and endothelial dysfunction. The authors assessed the impact of age and physical activity on metabolic and vascular outcomes following meal consumption in healthy adults. The authors recruited four groups: younger active (age 22.1 ± 1.4 years; n = 9), younger inactive (age 22.6 ± 3.7 years; n = 8), older active (age 68.4 ± 7.7 years; n = 8), and older inactive (age 67.7 ± 7.2 years; n = 7). The metabolic outcomes were measured at the baseline and hourly for 6 hr post high-fat meal consumption (12 kcal/kg; 63% fat). Flow-mediated dilation was measured at the baseline, 2 hr, and 4 hr postmeal. The total area under the curve for triglycerides was significantly lower in the more active groups, but did not differ based on age (younger active = 6.5 ± 1.4 mmol/L × 6 hr, younger inactive = 11.7 ± 4.8, older active = 6.8 ± 2.7, older inactive = 12.1 ± 1.7; p = .0004). After adjusting for artery diameter, flow-mediated dilation differed between groups at the baseline (younger active = 4.8 ± 1.6%, younger inactive = 2.5 ± 0.5, older active = 3.4 ± 0.9, older inactive = 2.2 ± 0.4; p < .001) and decreased significantly across groups 4 hr postmeal (mean difference = 0.82; 95% CI [0.02, 1.6]; p = .04). These findings highlight the beneficial effect of regular physical activity on postprandial lipemia, independent of age.
食用高脂餐可诱发餐后血脂异常和内皮功能障碍。作者评估了年龄和身体活动对健康成年人餐后代谢和血管结局的影响。作者招募了四组：年轻活跃组（年龄22.1±1.4岁；n = 9）、年轻不活跃组（年龄22.6±3.7岁；n = 8）、年长活跃组（年龄68.4±7.7岁；n = 8）和年长不活跃组（年龄67.7±7.2岁；n = 7）。在食用高脂餐（12千卡/千克；63%脂肪）后，于基线和之后6小时每小时测量代谢结局。在基线、餐后2小时和4小时测量血流介导的血管舒张。甘油三酯曲线下总面积在更活跃的组中显著更低，但在年龄方面无差异（年轻活跃组 = 6.5±1.4毫摩尔/升×6小时，年轻不活跃组 = 11.7±4.8，年长活跃组 = 6.8±2.7，年长不活跃组 = 12.1±1.7；p = 0.0004）。在调整动脉直径后，血流介导的血管舒张在基线时组间存在差异（年轻活跃组 = 4.8±1.6%，年轻不活跃组 = 2.5±0.5，年长活跃组 = 3.4±0.9，年长不活跃组 = 2.2±0.4；p < 0.001），且在餐后4小时各组间显著下降（平均差异 = 0.82；95%可信区间[0.02, 1.6]；p = 0.04）。这些发现凸显了规律身体活动对餐后血脂异常的有益作用，且与年龄无关。
