Zhang Geru, Li Qiwen, Yuan Quan, Zhang Shiwen
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Stem Cells Int. 2020 Aug 29;2020:8868593. doi: 10.1155/2020/8868593. eCollection 2020.
Stem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomandibular joint, cranial sutures, and periodontium. These cells exhibit self-renewal and multidirectional differentiation abilities. Here, we summarized the properties of craniofacial skeletal stem cells, based on their spatial distribution. Specifically, we focused on the genetic fate mapping of stem cells, by exploring specific stem cell markers and observing their lineage commitment in both the homeostatic and regenerative states. Finally, we discussed their application in regenerative medicine.
干细胞在颅面骨的发育、稳态维持和再生过程中发挥着不可替代的作用。在不同的干细胞微环境中已鉴定出多种组织驻留型颅面骨骼干细胞群，包括颅骨骨膜、颌骨骨髓、颞下颌关节、颅缝和牙周组织。这些细胞具有自我更新和多向分化能力。在此，我们基于颅面骨骼干细胞的空间分布总结了其特性。具体而言，我们通过探索特定的干细胞标志物并观察它们在稳态和再生状态下的谱系定向，着重研究了干细胞的遗传命运图谱。最后，我们讨论了它们在再生医学中的应用。
